Results 191 to 200 of about 3,504,331 (315)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Pattern formation, ruptures, and repairs in treatments of personality disorders: an idiographic case series study. [PDF]

Front Hum Neurosci
Høgenhaug SS, Kongerslev MT, Orsucci F, Zimatore G, Steffensen SV, Ekberg A, Campanella M, Schiepek G, Kjaersdam Telléus G.   +8 more
europepmc   +1 more source

Phenotypic plasticity: A missing element in the theory of vegetation pattern formation. [PDF]

Proc Natl Acad Sci U S A, 2023
Bennett JJR, Bera BK, Ferré M, Yizhaq H, Getzin S, Meron E.   +5 more
europepmc   +1 more source

Various scenarios of the cell pattern formation in Arabidopsis lateral root

, 2014
Jolanta Białek, Izabela Potocka, Joanna Szymanowska-Pułka   +2 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in <i>Chlamydomonas</i>. [PDF]

Proc Natl Acad Sci U S A
Wang Z, Tsang ACH.
europepmc   +1 more source

Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis. [PDF]

Bull Math Biol, 2023
Fraga Delfino Kunz C, Gerisch A, Glover J, Headon D, Painter KJ, Matthäus F.   +5 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A Non-Autonomous Amphoteric Metal Hydroxide Oscillations and Pattern Formation in Hydrogels. [PDF]

Molecules
Német N, Lawson HS, Itatani M, Rossi F, Suematsu NJ, Kitahata H, Lagzi I.   +6 more
europepmc   +1 more source

PIN49 SPREAD PATTERN FORMATION OF H5NI-AVIAN INFLUENZA AND ITS IMPLICATIONS FOR CONTROL STRATEGIES

, 2008
VRSK Duwuri, Runjuan Liu, Jtk Wu
openalex   +1 more source