Results 121 to 130 of about 45,642 (272)

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Illuminance and luminance distributions of a prototype ambient illumination system for Space Station Freedom [PDF]

Preliminary results of research conducted in the late 1970's indicate that perceptual qualities of an enclosure can be influenced by the distribution of illumination within the enclosure.
Hayes, B. C., Mullican, R. C.
core   +1 more source

Intelligent Stain‐Free Histology on Structural Colorimetric Nanocavities

Advanced Science, EarlyView.
Chen and Gan et al. introduce a label‐free imaging platform using inexpensive Nanocavity‐on‐Silicon (NOS) slides. These slides transform subtle tissue variations into vivid structural colors, enabling high‐contrast histological imaging under a regular optical microscope. This stain‐free approach reveals morphological details comparable to traditional H&
Qizhe Chen, Yifei Ren, Lijie Hu, Yanyan Li, Wenyue Liang, Jin Wang, Han Gao, Xinhai Wang, Jiajun Li, Qiutao He, Yingfeng Zhu, Haifeng Hu, Qiwen Zhan, Imed Gallouzi, Jasmeen Merzaban, Di Wang, Zunguo Du, Xiaodong Gu, Qiaoqiang Gan   +18 more
wiley   +1 more source

N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: Glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population

Clinical Interventions in Aging, 2008
Mark A Babizhayev1, Leslie Burke2, Philip Micans3, Stuart P Richer4,51Innovative Vision Products, Inc., County of New Castle, Delaware, USA; 2Wise Choice Products LLC, London, England, United Kingdom; 3IAS Group, Sark, United Kingdom; 4Eye Clinic DVA ...
Mark A Babizhayev, Leslie Burke, Philip Micans, Stuart P Richer   +3 more
doaj  

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Evaluation of Static and Dynamic Pupil and Light Sensitivity to a Single Drop of Various Concentrations of Low-Dose Atropine (0.01%, 0.025%, and 0.05%)

Life
This study aimed to evaluate the static and dynamic pupil changes, and light sensitivity following a single dose of low-dose atropine at concentrations of 0.01%, 0.025%, and 0.05% over a 24 h period.
Muteb K. Alanazi, Abdulmalik Almansour, Sarah S. Almutairi, Ahmad Alharbi, Mohammed S. Alhazmi, Ali Almustanyir, Basal H. Altoaimi, Meznah S. Almutairi, Mona M. Alamri, Maria Liu   +9 more
doaj   +1 more source

Human factors workplace considerations [PDF]

Computer workstations assume many different forms and play different functions today. In order for them to assume the effective interface role which they should play they must be properly designed to take into account the ubiguitous human factor.
Haines, Richard F.
core   +1 more source