Results 51 to 60 of about 2,100,297 (351)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Reading the Vernacular Interior: A Pattern Language for Reuse

open access: yesInteriority
Historic interiors are unique repositories of memory, yet conventional reuse practices often fail to grasp their cultural complexity, prioritising formal interventions over lived experience.
Nusrat Kamal Ritu   +2 more
doaj   +1 more source

Homeless Interactions with the Built Environment: A Spatial Pattern Language of Abandoned Housing

open access: yesUrban Science, 2019
Research demonstrates that homeless individuals use urban space in adaptive and endemic ways. Investigations at city and neighborhood scales would benefit from attention to homeless use of abandoned housing.
Abram Kaplan   +3 more
doaj   +1 more source

HDSR-Flor: A Robust End-to-End System to Solve the Handwritten Digit String Recognition Problem in Real Complex Scenarios

open access: yesIEEE Access, 2020
Automatic handwriting recognition systems are of interest for academic research fields and for commercial applications. Recent advances in deep learning techniques have shown dramatic improvement in relation to classic computer vision problems ...
Arthur Flor De Sousa Neto   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Graph Regularization Methods in Soft Detector Fusion

open access: yesIEEE Access, 2023
This paper presents a theoretical derivation of two new graph-based regularization methods for fusing the individual results of multiple detectors (two-class classifiers).
Addisson Salazar   +3 more
doaj   +1 more source

learning pattern languages using queries [PDF]

open access: yes, 1997
A pattern is a finite string of constant and variable symbols. For k≥1, we denote by kμΠ the set of all patterns in which each variable symbol occurs at most k times. In particular, we abbreviate μΠ for k=1. The language L(π) of a pattern π is the set of all strings obtained by substituting any non-null constant string for each variable symbol in π. In
Matsumoto, Satoshi, Shinohara, Ayumi
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Modelling children's negation errors using probabilistic learning in MOSAIC. [PDF]

open access: yes, 2003
Cognitive models of language development have often been used to simulate the pattern of errors in children’s speech. One relatively infrequent error in English involves placing inflection to the right of a negative, rather than to the left.
Croker, S, Gobet, F, Pine, J M
core   +1 more source

Improved Text Language Identification for the South African Languages

open access: yes, 2017
Virtual assistants and text chatbots have recently been gaining popularity. Given the short message nature of text-based chat interactions, the language identification systems of these bots might only have 15 or 20 characters to make a prediction ...
Duvenhage, Bernardt   +2 more
core   +1 more source

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