Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Nystagmus Estimation for Dizziness Diagnosis by Pupil Detection and Tracking Using Mexican-Hat-Type Ellipse Pattern Matching. [PDF]
Syahbana YA +5 more
europepmc +1 more source
Analysing the impact of global demographic characteristics over the COVID-19 spread using class rule mining and pattern matching [PDF]
Khan W +5 more
europepmc +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A New String Matching Algorithm for Searching Biological Sequences
String matching algorithms play a key role in many computer science problems, and in the implementation of computer software. This problem has received, and continues to receive a great deal of attention due to various applications in text ...
Osborne, Hugh, Klaib, Ahmad
core
From Controlled Scenarios to the Real World: Cross-Domain Degradation Pattern Matching for All-in-One Image Restoration. [PDF]
Fan J +7 more
europepmc +1 more source
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Fast and sensitive detection of targeted gene fusions using frequency minimizers and fuzzy pattern matching with Fuzzion2. [PDF]
Rice SV +23 more
europepmc +1 more source

