Results 101 to 110 of about 87,229 (314)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Fusion of dynamic and static features for gait recognition over time [PDF]

open access: yes, 2005
Gait recognition aims to identify people at a distance based on the way they walk. This paper deals with a problem of recognition by gait when time-dependent covariates are added, i.e.
Veres, Galina V   +7 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Human gait recognition with 3-D wavelets and kernel based subspace projections [PDF]

open access: yes
Gait recognition can be regarded as a problem of uniquely representing spatiotemporal surfaces associated with a person?s walking pattern in an efficient manner.
Masood, K.   +1 more
core  

Automated recognition of 3D CAD objects in site laser scans for project 3D status visualization and performance control

open access: yes, 2009
This paper presents a new approach that allows automated recognition of three-dimensional (3D) computer-aided design (CAD) objects from 3D site laser scans.
Akinci, Burcu   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

FROM SPEED PROFILE DATA TO ANALYSIS OF BEHAVIOUR

open access: yesIATSS Research, 2009
Classification of speed profiles is necessary to allow interpretation of automatic speed measurements in terms of road user behaviour. Aggregation without considering variation in individual profile shapes easily leads to aggregation bias, while ...
Aliaksei LAURESHYN
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Model-based Gait Recognition

open access: yes, 2009
Model-based Gait Recognition concerns identification using an underlying mathematical construct(s) representing the discriminatory gait characteristics (be they static or dynamic), with a set of parameters and a set of logical and quantitative ...
yam, cy, Nixon, Mark
core  

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