Results 91 to 100 of about 312,271 (274)

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Editorial: Deciphering population neuronal dynamics: from theories to experiments

Frontiers in Systems Neuroscience, 2023
Hongdian Yang, Woodrow L. Shew, Shan Yu, Artur Luczak, Carsen Stringer, Michael Okun   +5 more
doaj   +1 more source

Enhancing therapeutic reasoning: key insights and recommendations for education in prescribing

BMC Medical Education
Background Despite efforts to improve undergraduate clinical pharmacology & therapeutics (CPT) education, prescribing errors are still made regularly. To improve CPT education and daily prescribing, it is crucial to understand how therapeutic reasoning ...
Mariëlle G. Hartjes, Milan C. Richir, Yoann Cazaubon, Erik M. Donker, Ellen van Leeuwen, Robert Likic, Yves-Marie Pers, Joost D. Piët, Fabrizio De Ponti, Walter Raasch, Floor van Rosse, Jitka Rychlícková, Emilio J. Sanz, Markus Schwaninger, Susanna M. Wallerstedt, Theo P. G. M. de Vries, Michiel A. van Agtmael, Jelle Tichelaar, On behalf of the EACPT Education Working group   +18 more
doaj   +1 more source

A Novel Approach to Personalized Personality Assessment with the Attachment-Caregiving Questionnaire: First Evidence in Favor of Interpretation-Oriented Inventory Designs

Psychology International
In clinical psychology and psychiatry, personality is usually assessed using questionnaires developed through factor analysis (FA). Essential domains are identified, which correspond to questions/items defining a (sub)scale, and each question is rigidly ...
Marcantonio Gagliardi, Marina Bonadeni, Sara Billai, Gian Luca Marcialis   +3 more
doaj   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Distinguishing True From False Confessions Using Physiological Patterns of Concealed Information Recognition – A Proof of Concept Study Assistant Professor Honorary Research Fellow Associate Professor of Forensic Psychology

Wrongful conviction cases indicate that not all confessors are guilty. However, there is currently no validated method to assess the veracity of confessions. In this preregistered study, we evaluate whether a new application of the Concealed Information Test (CIT) is a potentially valid method to make a distinction between true and false admissions of ...
Linda Geven, Gershon Ben-Shakhar, Saul Kassin, Bruno verschuere   +3 more
openaire   +1 more source

From ELIZA to Conversational AI: Can a Chatbot Develop Emotions? Her as a Case Study [PDF]

Kaiak
The rapid evolution of conversational artificial intelligence (AI) has sparked an ongoing debate regarding its ability to replicate, or even experience, human emotions.
Danilo Petrassi
doaj