Results 271 to 280 of about 781,836 (318)

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

open access: yesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An   +7 more
wiley   +1 more source

The development of specific emotion comprehension components in 1285 preschool children. [PDF]

open access: yesSci Rep
Richard S   +7 more
europepmc   +1 more source

Recognition of temporal patterns: From engineering to psychology and back again.

open access: closedCanadian Journal of Experimental Psychology / Revue canadienne de psychologie expérimentale, 2007
An overview is presented on research conducted in our lab to quantify the underlying principles behind the recognition of temporal patterns. We have been developing a theory based upon pattern matching and time-series analysis, which allows us to model and understand how humans recognize familiar patterns evolving over time and how performance degrades
Willy Wong
openalex   +4 more sources

Elements of a cybernetic epistemology

Kybernetes, 2012
PurposeThe purpose of this paper is to analyze how pattern recognition can contribute to the behavioral options of a goal‐oriented system.Design/methodology/approachA functional approach is used to develop the necessary cybernetic structures of a pattern recognition unit that can store observations as new standards for pattern matching by itself and ...
H. Nechansky
openaire   +3 more sources

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