Results 41 to 50 of about 1,582 (167)

Frequency and neural correlates of pauses in patients with formal thought disorder

Frontiers in Psychiatry, 2013
Background: Pauses during speech may reflect the planning and monitoring of discourse, two processes putatively impaired in patients with schizophrenia, particularly those with formal thought disorder (FTD).
Kazunori eMatsumoto, Kazunori eMatsumoto, TIlo eKircher, Paul eStokes, Mickael J. Brammer, Peter eLIddle, Philip K McGuire   +6 more
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Intermittent motion in desert locusts: behavioural complexity in simple environments. [PDF]

PLoS Computational Biology, 2012
Animals can exhibit complex movement patterns that may be the result of interactions with their environment or may be directly the mechanism by which their behaviour is governed.
Sepideh Bazazi, Frederic Bartumeus, Joseph J Hale, Iain D Couzin   +3 more
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bedeutungsschwangere Pausen in Kognition und Interaktion: Pragmatische und psycholinguistische Perspektiven auf interkulturelle Kommunikation

Interkulturelles Forum der deutsch-chinesischen Kommunikation
Dieser Beitrag diskutiert die Frage, wie pragmatische Signale, insbesondere Gesprächspausen, in der interkulturellen Kommunikation als kognitiv und sozial bedeutsame Elemente fungieren.
Pleyer Michael, Qing Zhang Elizabeth, Żywiczyński Przemysław, Matzinger Theresa   +3 more
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Méthode d’analyse des pauses pour l’évaluation de troubles cognitifs subtils appliquée au Cancer-Related Cognitive Impairment.

Glossa
Contexte. L’analyse de la parole permet de repérer des troubles cognitifs subtils, notamment car la prosodie contient des éléments fins, comme les pauses, qui peuvent être des marqueurs comportementaux de Troubles NeuroCognitifs.
Amélie Richard, Fabrice Hirsch, Sophie Jacquin-Courtois   +2 more
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Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo

eLife, 2018
The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses.
Stefano Zucca, Aya Zucca, Takashi Nakano, Sho Aoki, Jeffery Wickens   +4 more
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Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

La lingüística de corpus como herramienta de análisis literario: La narración retrospectiva de los silencios en las novelas de Galdós [PDF]

Sintagma, 2019
This article looks into the potential of corpuslinguistic approaches in the analysis of literary texts written in Spanish. To do so, we have built a corpus of study made up of Pérez Galdós’ fictional narratives (approximately 6.4 million words), which ...
Guadalupe Nieto Caballero
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