Results 41 to 50 of about 2,962 (257)

ASSESSMENT OF FLEXIBLE PAVEMENT CONDITION USING PCI: A CASE STUDY

Revista Eídos
The pavement condition index (PCI) is an inexpensive and simple method to evaluate pavement distresses. The main purpose of this study is to identify and evaluate pavement distress of Jalalabad highway using pavement condition index (PCI) to find a ...
Rohid Dost, kaiwaan Abdulhai, Sayed Javid Azimi, Mohammad Haroon Sarwary   +3 more
doaj   +1 more source

Assessment of Pavement Structural Conditions and Remaining Life Combining Accelerated Pavement Testing and Ground-Penetrating Radar

Remote Sensing, 2023
The inspection and monitoring of structural conditions are crucial for the maintenance of semi-rigid base pavement. To achieve the inverse calculation of material parameters and obtain the mechanical response of asphalt pavement, a method of modulus ...
Zhen Liu, Qifeng Yang, Xingyu Gu
doaj   +1 more source

Development of Korea Airport Pavement Condition Index for Panel Rating

Applied Sciences, 2022
Airports strive to prevent safety issues, such as foreign object debris (FOD), by pavement management using the pavement condition index (PCI). The index is used in decision-making processes for overall pavement maintenance and repair, such as the ...
Nam-Hyun Cho, Hong-Joon Kwon, Young-Chan Suh, Jangrak Kim   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Condition indices for rigid pavements: A comparative analysis of state DOTs using Michigan PMS data

Journal of Road Engineering
Pavement infrastructure is vital in providing services and links between various sectors of society. Therefore, the preservation and maintenance of these roads are critical to attaining a pavement network in good condition throughout its service life ...
Rahul Raj Singh, Mumtahin Hasnat, Muhammed Emin Kutay, Syed Waqar Haider, James Bryce, Bora Cetin   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Road Pavement Condition Index (PCI) Evaluation and Maintenance: A Case Study of Yemen

Organization, Technology and Management in Construction: An International Journal, 2017
The pavement condition index (PCI) is a simple, convenient and inexpensive way to monitor the condition of the surface of roads, identify maintenance and rehabilitation (M-and-R) needs as well as ensure that road maintenance budgets are spent wisely.
Karim Fareed M.A., Rubasi Khaled Abdul Haleem, Saleh Ali Abdo   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source