Results 51 to 60 of about 9,841 (297)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Discussion on the Determination Methods for Crack Width Collection Capacity of Highway Pavement [PDF]

E3S Web of Conferences
This paper summarizes the main detection technologies for highway pavement cracks and the judgment methods for crack width, and introduces the existing evaluation standards and metrological verification systems.
Wang Meixia, Zhang Zhenwei, Hou Zhaohan, Jin Mingyang, Ji Ao   +4 more
doaj   +1 more source

Semi-Supervised Semantic Segmentation Using Adversarial Learning for Pavement Crack Detection

IEEE Access, 2020
Regular inspection of pavement conditions is important to guarantee the safety of transportation. However, current approaches are time-consuming and subjective, which requires the technician to annotate each training image exactly pixel by pixel. To ease
Gang Li, Jian Wan, Shuanhai He, Qiangwei Liu, Biao Ma   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Automatic Pixel-Level Pavement Crack Detection Using Information of Multi-Scale Neighborhoods

IEEE Access, 2018
Robust automatic pavement crack detection is critical to automated road condition evaluation. However, research on crack detection is still limited and pixel-level automatic crack detection remains a challenging problem, due to heterogeneous pixel ...
Dihao Ai, Guiyuan Jiang, Lam Siew Kei, Chengwu Li   +3 more
doaj   +1 more source

Iteratively Optimized Patch Label Inference Network for Automatic Pavement Disease Detection

, 2021
We present a novel deep learning framework named the Iteratively Optimized Patch Label Inference Network (IOPLIN) for automatically detecting various pavement diseases that are not solely limited to specific ones, such as cracks and potholes.
Huang, Sheng, Huangfu, Luwen, Li, Ren, Tang, Wenhao, Zhao, Qiming   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Automatic Detection of Urban Pavement Distress and Dropped Objects with a Comprehensive Dataset Collected via Smartphone

Buildings
Pavement distress seriously affects the quality of pavement and reduces driving comfort and safety. The dropped objects from vehicles have increased the risks of traffic accidents.
Lin Xu, Kaimin Fu, Tao Ma, Fanlong Tang, Jianwei Fan   +4 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source