Results 41 to 50 of about 35,755 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Performance Evaluation of Open Graded Base Course with Doweled and Non-Doweled Transverse Joints [PDF]

, 2010
The objectives of this study were to investigate the performance of 20-year old doweled/non-doweled and dense-graded/permeable base test sections on three concrete pavement segments in Wisconsin: USH 18/151 in Iowa and Dane counties, STH 29 in Brown ...
Crovetti, James, Owusu-Ababio, Samuel, Schmitt, Robert   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Determining the relationship between rock colour and the type of physical weathering on desert pavements in arid landscapes, Ras Al Khaimah, UAE [PDF]

, 2008
Despite opposition to the theory that diurnal heat fluxes within desert rocks cause enough internal stress to form cracks on clasts leading to the break down of the desert material, this study provides further evidence that this is a credible process in ...
O.J.H. Swift
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Intelligent identification of pavement cracks based on PSA-Net

Frontiers in Environmental Science, 2023
The identification of pavement cracks is critical for ensuring road safety. Currently, manual crack detection is quite time-consuming. To address this issue, automated pavement crack-detecting technology is required.
Xuan Lin, Jian Zhang, Daifeng Wu, Enhong Meng, Maoyi Liu, Meng Li, Fuliu Gao   +6 more
doaj   +1 more source

Performance of TenCate Paving Interlayers in Asphalt Concrete Pavements [PDF]

, 2017
As a continued effort of a previously completed project entitled “Performance of TenCate Mirafi PGM-G4 Interlayer-Reinforced Asphalt Pavements in Alaska,” this project evaluated two newly modified paving interlayers (TruPave and Mirapave) through overlay,
Li, Lin, Liu, Jenny, Zhao, Sheng
core  

An analytical and experimental assessment of flexible road ironwork support structures [PDF]

, 2003
This paper describes work undertaken to investigate the mechanical performance of road ironwork installations in highways, concentrating on the chamber construction.
A.C. Collop, ANSYS revision 5.7, Ashby M. F., Brown S. F., Brown S. F., Brown S. F., Collop A. C., Cope R. J., F. A. Mohammad, Highways Agency, Popov E. P., S.F. Brown   +11 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Pavement crack image acquisition methods and crack extraction algorithms: A review

Journal of Traffic and Transportation Engineering (English ed. Online), 2019
The extraction of pavement cracks is always a hard task in image processing. In airport and road construction, cracking is the main factor for pavement damage, which can decrease the quality of pavement and affect transportation seriously.
Weixing Wang, Mengfei Wang, Hongxia Li, Heng Zhao, Kevin Wang, Changtao He, Jun Wang, Sifan Zheng, Jiabin Chen   +8 more
doaj   +1 more source