Results 41 to 50 of about 8,421,122 (309)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
MEPDG Work Plan Task No. 8: Validation of Pavement Performance Curves for the Mechanistic-Empirical Pavement Design Guide, 2009 [PDF]
, 2009 The objective of this research is to determine whether the nationally calibrated performance models used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) provide a reasonable prediction of actual field performance, and if the desired accuracy ...
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GIS Based Pavement Maintenance: A Systematic Approach [PDF]
, 2011 According to 2008 Federal Highway Administration (FHWA) statistics, there are 2,734,102 miles of paved public roads in the United Sates, with an additional 1,324,245 miles of unpaved public roads.
Kmetz, Robert J
core +1 more source
Cumulative Distribution-Based Method for Pavement Performance Modeling
Journal of Highway and Transportation Research and DevelopmentPavement performance prediction is the basis for maintenance decisions. Predicting future pavement conditions accurately and efficiently helps determine the optimal maintenance time, select appropriate measures, and allocate rehabilitation funds ...
Chenhao Tu +4 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Predicting Rutting Development of Pavement with Flexible Overlay Using Artificial Neural Network
Applied Sciences, 2023 Pavement maintenance and repair is a crucial part of pavement management systems. Accurate and reliable pavement performance prediction is the prerequisite for making reasonable maintenance decisions and selecting suitable repair schemes.
Chunru Cheng +3 more
doaj +1 more source
, 2016 In the early 1990s the Indiana Department of Transportation (INDOT) developed a five-year warranty specification for asphalt pavements with the first project being built in 1996. In 2004, results indicated that the asphalt pavements built with the warranty specification had improved performance over the conventional asphalt pavements.
Leila Sadeghi +2 more
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
MEPDG Work Plan Task No. 7: Existing Pavement Input Information for the Mechanistic-Empirical Pavement Design Guide, 2009 [PDF]
, 2009 The objective of this study is to systematically evaluate the Iowa Department of Transportation’s (DOT’s) existing Pavement Management Information System (PMIS) with respect to the input information required for Mechanistic-Empirical Pavement Design ...
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