Results 191 to 200 of about 19,461 (219)

A novel PAX3 rearrangement in embryonal rhabdomyosarcoma

Cancer Genetics and Cytogenetics, 2009
Rhabdomyosarcoma is the most common soft tissue tumor seen in children and young adults, and it can be classified into 2 major histological subtypes, alveolar and embryonal. In the alveolar subtype, 2 recurrent chromosomal translocations, t(2;13)(q35;q14) and its variant t(1;13)(p36;q14), have been identified as the specific cytogenetic abnormalities ...
Hajime, Hosoi, Naoki, Kakazu, Eiichi, Konishi, Yasunari, Tsuchihashi, Satoshi, Hada, Eriko, Amaya, Yoshinobu, Nakabayahi, Akiko, Misawa-Furihata, Hiroko, Tabata-Maruyama, Tomoko, Iehara, Tohru, Sugimoto, Humitsugu, Yamane, Masayuki, Yamasaki, Kuninori, Shiwaku, Akio, Yanagisawa, Megumi, Ono, Kazuaki, Tokiwa, Naomi, Iwai, Mitsuoki, Hashiba, Tatsuo, Abe, Tadashi, Sawada   +20 more
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The Role of Pax3 and Pax7 in Development and Cancer

Critical Reviews™ in Oncogenesis, 1998
Pax genes consist of a family of transcription factors that are essentially required for the genesis of a variety of tissues and organs. Pax3 and Pax7 are specifically expressed in the dorsal neural tube and the developing somite. Loss-of-function mutations of Pax3 in Splotch mice and in Waardenburg syndrome in man revealed that Pax3 is necessary for ...
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Normal and Rearranged PAX3 Expression in Human Rhabdomyosarcoma

Cancer Genetics and Cytogenetics, 1998
PAX3, a member of the PAX-gene family, encodes a nuclear transcription factor that is transiently expressed in the neural tube and in muscle progenitor cells and regulates embryonal development in the mouse. Together with the FKHR gene it is involved in the t(2;13)(q35;q14), a specific translocation associated with alveolar rhabdomyosarcoma (ARMS).
FRASCELLA E, TOFFOLATTI L, ROSOLEN, ANGELO   +2 more
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PAX3 across the spectrum: from melanoblast to melanoma

Critical Reviews in Biochemistry and Molecular Biology, 2009
The PAX3 transcription factor is critical for the proper development of neural crest lineages including melanocytes. These cells show continued PAX3 expression from formation to differentiation. While many expression, misexpression and mutation studies clarify the importance of PAX3 in melanocyte development, less well understood, and more perplexing ...
Sandra, Medic, Melanie, Ziman
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TaqI and HindIII RFLPs at the chicken PAX3 locus

Animal Genetics, 1996
International ...
Girard-Santosuosso, O., Lantier, Isabelle, Millet, N., Mouline, Christian, Guillot, J.F., Protais, J., Colin, P., Beaumont, Catherine, Lantier, Frédéric   +8 more
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Pax3^GFP, a new reporter for the melanocyte lineage, highlights novel aspects of PAX3 expression in the skin

Pigment Cell & Melanoma Research, 2012
SummaryThe paired box gene 3 (Pax3) is expressed during pigment cell development. We tested whether the targeted allele Pax3GFP can be used as a reporter gene for pigment cells in the mouse. We found that enhanced green fluorescent protein (GFP) can be seen readily in every melanoblast and melanocyte in the epidermis and hair follicles of Pax3GFP ...
Djiane-Zaouche, Johanna, Campagne, Cécile, Reyes-Gomez, Edouard, Gadin-Czerw, Stéphanie, Bernex, Florence, Louise, Anne, Relaix, Frédéric, Buckingham, Margaret, Panthier, Jean-Jacques, Aubin Houzelstein, Geneviève   +9 more
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Expression of PAX3 in Ewing's Sarcoma Family of Tumors

Biochemical and Molecular Medicine, 1997
The Ewing's sarcoma family of tumors (ESFT) is the second most common pediatric malignancy originating in the bone and is characterized by the t(11; 22) translocation. PAX3, a member of the paired box family of genes, is expressed during embryonal development of neural crest cells and is involved in the t(2; 13) translocation found in alveolar ...
T W, Schulte, J A, Toretsky, E, Ress, L, Helman, L M, Neckers   +4 more
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Role ofPax3/7in the tectum regionalization

Development, 2001
Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pax7 in the diencephalon and ventral mesencephalon ...
E, Matsunaga, I, Araki, H, Nakamura
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The mutation status of PAX3 and p53 genes in medulloblastoma.

Anticancer research, 1998
The p53 and PAX3 genes were examined by PCR, SSCP and DNA sequencing methods in 50 and 58 paraffinembedded medullablastoma tissues, respectively. Four novel mutations were identified among these samples in exon 5 of the p53 gene. Two tumours showed a G to A transition.
Wang, Weiguang, Kumar, Patricia, Wang, Weizhi, Whalley, J., Schwarz, Martin, Malone, Geraldin, Haworth, Andrea, Kumar, Shant   +7 more
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PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets

Molecular Cell, 2022
W Hayes McDonald, Hillary M Layden, Scott C Borinstein   +2 more
exaly