Results 101 to 110 of about 323,991 (387)

Free‐Form Microfluidic Microneedle Array Patches

open access: yesAdvanced Functional Materials, EarlyView.
Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates   +11 more
wiley   +1 more source

The development of a complementary expendable launch vehicle interface for an STS deployable payload [PDF]

open access: yes
The development is described of an interface, the Titan Payload Adapter (TPA), between a Space Transportation System (STS) deployable payload and an expendable launch vehicle (ELV).
Eubanks, ED, Gibb, John
core   +1 more source

A simultaneous spin/eject mechanism for aerospace payloads [PDF]

open access: yes, 1976
A simultaneous spin/eject mechanism was developed for aerospace applications requiring a compact, passive device which would accommodate payload support and controlled-release functions, and which would provide a highly accurate spin-ejection motion to ...
Banks, T. N., Palmer, G. D.
core   +1 more source

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles

open access: yesAdvanced Healthcare Materials, EarlyView.
We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak   +6 more
wiley   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

open access: yesAdvanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Coupled loads analysis for Space Shuttle payloads [PDF]

open access: yes
Described here is a method for determining the transient response of, and the resultant loads in, a system exposed to predicted external forces. In this case, the system consists of four racks mounted on the inside of a space station resource node module
Eldridge, J.
core   +1 more source

FPGA-based operational concept and payload data processing for the Flying Laptop satellite [PDF]

open access: yes, 2009
Flying Laptop is the first small satellite developed by the Institute of Space Systems at the Universität Stuttgart. It is a test bed for an on-board computer with a reconfigurable, redundant and self-controlling high computational ability based on the ...
Böhringer, Felix   +5 more
core   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah   +9 more
wiley   +1 more source

Shuttle payload vibroacoustic test plan evaluation. Free flyer payload applications and sortie payload parametric variations [PDF]

open access: yes
A preliminary assessment of vibroacoustic test plan optimization for free flyer STS payloads is presented and the effects on alternate test plans for Spacelab sortie payloads number of missions are also examined.
Gongloff, H. R., Stahle, C. V.
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo   +3 more
wiley   +1 more source

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