Results 121 to 130 of about 323,991 (387)

Magnetic Resonance Imaging‐Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle‐Loaded Lipid Nanoparticles

open access: yesAdvanced Healthcare Materials, EarlyView.
The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee   +5 more
wiley   +1 more source

Communications payload concepts for geostationary facilities [PDF]

open access: yes
Summarized and compared are the major results of two NASA sponsored studies that defined potential communication payload concepts to meet the satellite traffic forecast for the turn of the century for the continental US and Region 2 of the International ...
Lekan, Jack, Poley, William A.
core   +1 more source

Adaptive Fuzzy Backstepping Sliding Mode Control for a 3-DOF Hydraulic Manipulator with Nonlinear Disturbance Observer for Large Payload Variation

open access: yesApplied Sciences, 2019
The paper proposes an adaptive fuzzy position control for a 3-DOF hydraulic manipulator with large payload variation. The hydraulic manipulator uses electrohydraulic actuators as primary torque generators to enhance carrying payload of the manipulator ...
H-V-A Truong   +4 more
semanticscholar   +1 more source

Biodegradable Implantable Electronics with Wireless Technology for Real‐Time Clinical Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
The article explores how bioresorbable implantable electronics merge wireless communication and power delivery with biodegradable materials to enable real‐time clinical applications. It highlights advances in materials, system design, and medical uses across neural, cardiovascular, digestive, immune, and drug‐delivery systems.
Myeongki Cho   +4 more
wiley   +1 more source

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

open access: yesAdvanced Healthcare Materials, EarlyView.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao   +4 more
wiley   +1 more source

Autonomous Payload Thermal Control

open access: yes, 2023
In small satellites there is less room for heat control equipment, scientific instruments, and electronic components. Furthermore, the near proximity of electronic components makes power dissipation difficult, with the risk of not being able to control the temperature appropriately, reducing component lifetime and mission performance.
openaire   +2 more sources

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.

open access: yesCancer Research, 2016
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood.
Fu Li   +10 more
semanticscholar   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

open access: yesAdvanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle   +9 more
wiley   +1 more source

Research on Multi-Dimensional Packet Classification Algorithm

open access: yesDianxin kexue, 2014
With the increase of network services, multi-dimensional packet classification technology has become a core technology for network devices in the next generation internet.
Hanbing Liu, Yali Yang, Aina Hu
doaj  

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