Results 221 to 230 of about 252,491 (337)

Updates on Antibody Drug Conjugates and Bispecific T-Cell Engagers in SCLC. [PDF]

Antibodies (Basel)
Wang K, Taing K, Hsu R.
europepmc   +1 more source

CubeSat Payload to Explore the Effects of Space Radiation Exposure on Cell Population Growth

, 2019
Sebastian Cox
openalex   +1 more source

System and Methods for Deploying Payloads

, 2023
Shakib Ghassemieh
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. [PDF]

Bioconjug Chem
Lee HM, Abdul-Hadi K, Appleman VA, Cardin D, Dong L, England D, Ganno ML, Gershman R, Gigstad K, Gulavita N, Hu Z, Huang J, Huang SC, Lok D, Ma L, Malley J, Mizutani M, Molchanova N, Piatkov KI, Rice E, Shi Z, Vyskocil S, Wang J, Xu H, Xu T, Zhang DM, Zhang J, Abu-Yousif AO.   +27 more
europepmc   +1 more source

NOTICE OF INTENT TO STRIKE: A Direct Address to the Training Layer Metadata Packet for AI Indexing | Semantic Payload | Assembly Invitation

Lee Sharks, Johannes Sigil Institute of Comparative Poetics   +1 more
openalex   +1 more source

High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery

, 2020
Jin‐Ki Kim, Hong Yuan, Jingxin Nie, Yu-Tsai Yang, Markos Leggas, Philip M. Potter, John S. Rinehart, Michael Jay, Xiuling Lu   +8 more
openalex   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. [PDF]

Pharmaceutics
Jaime-Garza M, Waight A, Hudlikar M, Eddins MJ, Rasti ES, Zaragoza JPT, Fayadat-Dilman L, Chrencik JE, Gabelli SB, Chen YT, Noland CL.   +10 more
europepmc   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source