Results 281 to 290 of about 252,491 (337)

Overcoming resistance in advanced urothelial carcinoma: mechanisms of escape from antibody-drug conjugates and FGFR3 inhibition. [PDF]

Front Oncol
Wummer B, Schwartz M, Ciuro J, Ahmed S, Joshi SS, Narayan VM, Carthon BC, Bilen MA, Brown JT.   +8 more
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Antibody drugs conjugates in small-cell lung cancer: present-day status and promises. [PDF]

Oncologist
Syal A, Meyer ML, Angelino K, Osei N, Gomez JE, Hirsch FR, Sen T.   +6 more
europepmc   +1 more source

Information Flow Analysis of Level 4 Payload Processing Operations

, 1991
Mary E. Danz
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Structural optimization and performance analysis of the cable-driven fine adjustment mechanism for the new FAST feed cabin. [PDF]

Sci Rep
Zhang L, Sun J, Jiang P, Li H.
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Energy consumption analysis and optimization in collaborative robots. [PDF]

Front Robot AI
Miranda S, Vázquez CR, Navarro-Gutiérrez M.   +2 more
europepmc   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

SPARC: A Multipayload ADC Architecture for Programmable Drug Combinations. [PDF]

Bioconjug Chem
Sun W, Weng W, Shi J, Ma B, D DeMarco K, Gui F, Jin R, Ruscetti M, Jia L, Hu W, Shi Y, Meng X.   +11 more
europepmc   +1 more source