Results 31 to 40 of about 252,491 (337)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Hybrid fuzzy and sliding-mode control for motorised tether spin-up when coupled with axial vibration [PDF]

, 2009
A hybrid fuzzy sliding mode controller is applied to the control of motorised tether spin-up coupled with an axial oscillation phenomenon. A six degree of freedom dynamic model of a motorised momentum exchange tether is used as a basis for interplanetary
Brian O'Dell, Cartmell M P, Chen Y, Chen Y, Emelyanov S V, Itkis Y, John Y Hung, Kevin M Passino, M P Cartmell, Ng K C, Slotine J J E, Slotine J J E, Utkin V A, Y Chen   +13 more
core   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Hybrid fuzzy sliding mode control for motorised space tether spin-up when coupled with axial and torsional oscillation [PDF]

, 2010
A specialised hybrid controller is applied to the control of a motorised space tether spin-up space coupled with an axial and a torsional oscillation phenomenon.
Cartmell, M., Chen, Y.
core   +1 more source

Design and Prototyping of Topology‐Optimized, Additively Manufactured Lightweight Components for Space Robotic Systems: A Case Study

Advanced Engineering Materials, EarlyView.
The results demonstrate a simulation‐driven workflow that applies LSB topology optimization with additive manufacturing constraints to mission‐specific load cases, integrating European Cooperation for Space Standardization compliant verification and manufacturability to develop structurally efficient rover suspension components.
Stelios K. Georgantzinos, Grigorios Kostopoulos, Eleni Papadopoulou, Stefanos Voulgaris, Alexandra Tseni, Panteleimon Bakalis, Maria N. Gkara, Chara Ch. Mitropoulou, Georgios Kazakis, Alin Munteanu, Jeremi Gancet, Nikos D. Lagaros   +11 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Enhanced Characterization of Lysine-Linked Antibody Drug Conjugates Enabled by Middle-Down Mass Spectrometry and Higher-Energy Collisional Dissociation-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation and Ultraviolet Photodissociation

Antibodies
As the development of new biotherapeutics advances, increasingly sophisticated tandem mass spectrometry methods are needed to characterize the most complex molecules, including antibody drug conjugates (ADCs).
Eleanor Watts, Aarti Bashyal, Sean D. Dunham, Christopher M. Crittenden, Jennifer S. Brodbelt   +4 more
doaj   +1 more source

Development of a Non-Separable Integer-to-Integer Wavelet Transform-Based Digital Image Steganography System

Applications of Modelling and Simulation, 2022
This paper develops a high payload and imperceptible digital image steganography system using a non-separable integer wavelet transform and diamond encoding.
M. A. Idakwo, M. B. Mu’azu, E. A. Adedokun, B. O. Sadiq   +3 more
doaj  

Productivity and costs of the mechanised cut-to-length wood harvesting system in clear-felling operations

Journal of Forest Science, 2007
A study of labour productivity was conducted in fully mechanised harvesting technologies. The study revealed that the productivity of harvesters was particularly affected by the average tree volume of the felled trees, and the productivity of forwarders ...
R. Jiroušek, R. Klvač, A. Skoupý
doaj   +1 more source