Results 151 to 160 of about 65,544 (296)

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

open access: yesAdvanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen   +3 more
wiley   +1 more source

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling   +14 more
wiley   +1 more source

An Automated Lab‐On‐A‐Chip Approach for Pollen Tube Growth Manipulation in a Controlled Chemical Environment

open access: yesAdvanced Science, EarlyView.
Here, a microfluidic‐based robotic lab‐on‐a‐chip (LoC) device is presented for automated, continuous‐flow investigation and manipulation of single pollen tube growth under precisely controlled chemical gradients. This closed‐loop system streamlines data collection and analysis while enhancing experimental precision compared to manual methods ...
Jiawei Zhu   +10 more
wiley   +1 more source

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee   +8 more
wiley   +1 more source

Vinyl Acetate‐Enhanced Polyvinyl Chloride Gel with High Electroadhesion and Self‐Heating‐Tunability for Soft Robots in Freezing Environments

open access: yesAdvanced Science, EarlyView.
This study presents a vinyl acetate‐enhanced electroactive polyvinyl chloride gel with low‐voltage deformation, strong electro‐adhesion, and controlled heating. Leveraging these synergistic properties, this work develops soft robots capable of fast locomotion, swarm reconfiguration, and low‐temperature operation (‐50°C).
Chang Wei   +11 more
wiley   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

open access: yesAdvanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim   +7 more
wiley   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

open access: yesAdvanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen   +11 more
wiley   +1 more source

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