Results 161 to 170 of about 65,544 (296)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

open access: yesAdvanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu   +13 more
wiley   +1 more source

Convolutional neural network and wavelet composite against geometric attacks a watermarking approach. [PDF]

open access: yesSci Rep
Lakshmi C   +9 more
europepmc   +1 more source

Re‐Purposing a Modular Origami Manipulator Into an Adaptive Physical Computer for Machine Learning and Robotic Perception

open access: yesAdvanced Science, EarlyView.
Reservoir computing in the physical domain promises an alternative, more energy‐efficient approach to machine learning. However, the correlation between mechanical design and computing power remains elusive. This study sheds light on this gap by repurposing a meta‐stable modular origami manipulator into an adaptive computing kernel that can perform ...
Jun Wang, Suyi Li
wiley   +1 more source

Intravenous iRGD‐Guided, RBC‐Membrane Camouflaged Lactococcus Lactis Remodels Cold NSCLC and Enhances PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study presents an engineered probiotic platform, iRGD‐mRBC@FOLactis, combining red blood cell membrane cloaking and tumor‐penetrating peptide iRGD for enhanced PD‐1 blockade. The platform improves tumor targeting, immune cell activation and therapeutic efficacy in lung cancer, demonstrating significant promise in overcoming PD‐1/PD‐L1 therapy ...
Chen Chen   +9 more
wiley   +1 more source

Secure and intelligent 5G-enabled remote patient monitoring using ANN and Choquet integral fuzzy VIKOR. [PDF]

open access: yesSci Rep
Chinnaperumal S   +7 more
europepmc   +1 more source

Luminescent Nanocucurbits Enable Spatiotemporal Co‐Delivery of Hydrophilic and Hydrophobic Chemotherapeutic Agents

open access: yesAdvanced Science, EarlyView.
A cucurbit‐shaped luminescent nanoparticle (nanocucurbit) is engineered through the self‐assembly of polypeptides conjugated with aggregation‐induced emission (AIE) fluorophore. The resulting nanocucurbit exhibits approximately two‐fold higher cellular internalization efficiency compared to its spherical counterparts.
Ping Wei   +4 more
wiley   +1 more source

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