High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline
Advanced Science, EarlyView.This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam +3 more
wiley +1 more source
Advanced Science, EarlyView.A Cas12a@MnO2 nanosponge (hMNS) nanoprobe is engineered to overcome the intracellular delivery and kinetic barrier of the conventional CRISPR/Cas12a system via GSH‐responsive release and Mn2⁺‐enhanced trans‐cleavage. It enables preamplification‐free detection of mRNA with single‐cell sensitivity, differentiation of mRNA expression between breast cancer
Wen‐jing Liu +3 more
wiley +1 more source
Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure. [PDF]
Int J Mol SciXu S, Xie L, Dai R, Lyu Z.
europepmc +1 more source
Nanozyme‐Engineered Probiotic Microneedle Patch for Chronic Diabetic Wound Therapy
Advanced Science, EarlyView.This work introduces a robust living‐materials‐based strategy that integrates microbial therapy with catalytic nanotechnology for effective management of chronic infected wounds via alleviating reactive oxygen species (ROS), combating bacterial infection, relieving hypoxia, and exerting anti‐inflammatory effects.
Xueyang Wang +7 more
wiley +1 more source
Highly Accurate Attitude Estimation of Unmanned Aerial Vehicle Payloads Using Low-Cost MEMS. [PDF]
Micromachines (Basel)Zhou X +5 more
europepmc +1 more source
Intracellular Mechanical Stress‐Mediated Autophagy Cell Death via Nanospikes for Cancer Treatment
Advanced Science, EarlyView.Nanospikes with tunable morphology at the nanoscale induce lysosomal membrane damage by generating localized mechanical stress, activating Galectin‐3 (Gal3)‐Trim16‐mediated autophagic cell death. Finite element analysis and laser‐triggered spike ablation enable precise control of intracellular force signaling and cytotoxicity, offering a ...
Yingze Li +11 more
wiley +1 more source
AI-embodied multi-modal flexible electronic robots with programmable sensing, actuating and self-learning. [PDF]
Nat CommunLi J +10 more
europepmc +1 more source
Advanced Science, EarlyView.Ulcerative colitis therapy requires precise drug targeting. This study engineers a probiotic E. coli Nissle 1917 to surface‐display ANXA5, enabling specific binding to phosphatidylserine (PS) exposed on inflamed colonic epithelium for enhanced targeting and colonization.
Siqi Hua +6 more
wiley +1 more source
Anomaly detection in encrypted network traffic using self-supervised learning. [PDF]
Sci RepSattar S +7 more
europepmc +1 more source
A Pill That Prints‐An Ingestible Bioprinter for Non‐Invasive Structured Bioink Deposition
Advanced Science, EarlyView.A first‐of‐a‐kind swallowable bioprinter performs in‐situ bioink deposition and patterning directly over disease sites without tethers, electronics, or invasive surgery. Combining magnetic guidance with near‐infrared triggering enables functionality within a small footprint.
Sanjay Manoharan, Vivek Subramanian
wiley +1 more source