Results 261 to 270 of about 1,938,290 (341)

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

open access: yesAdvanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song   +6 more
wiley   +1 more source

A Study on the Cell Layer Patterns of a Citrus Periclinal Chimera Reveals β‐Cryptoxanthin Regulation in Citrus Fruits

open access: yesAdvanced Science, EarlyView.
Researchers have identified a citrus chimera with distinctive tissue origins and carotenoid profiles. It is discovered that fruit tissues develop from all three cell layers but in different proportions. A key transcription factor, MYB107, regulates β‐cryptoxanthin production by directly activating carotenoid biosynthesis genes, explaining why some ...
Chi Zhang   +8 more
wiley   +1 more source

Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near‐Infrared Diffuse Reflectance Spectroscopy and Multi‐Spectral Optoacoustic Tomography

open access: yesAdvanced Science, EarlyView.
Authors present a novel approach combining multispectral optoacoustic tomography and diffuse reflectance spectroscopy for noninvasive assessment of body composition, including water, lipid, and collagen in skin and muscles. Its high molecular and spatial specificity offers improved diagnostic potential for conditions like obesity and sarcopenia ...
Denis Davydov   +9 more
wiley   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

open access: yesAdvanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo   +17 more
wiley   +1 more source

Medicare Part D Use and Costs for Immune-Mediated Neurologic Therapies.

open access: yesJAMA Netw Open
Wong KH   +12 more
europepmc   +1 more source

Microbial Community Succession Sustains Fish Diversity in the Upper Yangtze River Reserve

open access: yesAdvanced Science, EarlyView.
Critical for river ecosystem sustainability, fish diversity relates to multitrophic microbes. This upper Yangtze FNNR study used eDNA to examine microbial succession‐fish links, finding key drivers, distinct assembly processes, and that microbial cross‐trophic interactions benefit fish, offering conservation insights.
Jiaxin Huang   +12 more
wiley   +1 more source

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