Results 281 to 290 of about 1,938,290 (341)

Single‐Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion

Advanced Science, EarlyView.
Single‐cell transcriptomics and clinical data show that during myasthenia gravis (MG) exacerbation, bone marrow mature neutrophils expand and enter blood, with parallel increase of B‐cell activating factor (BAFF)–positive neutrophils. Experimental autoimmune myasthenia gravis (EAMG) confirms a pathogenic interferon‐γ (IFN‐γ)–neutrophil–BAFF axis ...
Zhaoxu Zhang, Jingya Dong, Mengyuan Qiu, Jie Bai, Xufeng Cheng, Xiaodong Song   +5 more
wiley   +1 more source

Seven Years of Participation Churn in the Medicare Quality Payment Program.

JAMA Netw Open
Lin MY, Carey K, Gidwani R, Hanchate AD.
europepmc   +1 more source

Reasonable Cost for Procedures: An Anonymous Survey of Healthcare Providers. [PDF]

J Health Econ Outcomes Res
Shin D, Cummings C, Cheng D, Dinh C, Im D, Tang T, Oh I, Han L, Carlson P, Harianja G, Razzouk J, Danisa O, Cheng W.   +12 more
europepmc   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Incentivizing Hospital Quality Through Care Bundling. [PDF]

Health Econ
Grašič K, Villaseñor A, Gaughan J, Gutacker N, Siciliani L.   +4 more
europepmc   +1 more source

Cytological Classification Diagnosis for Thyroid Nodules via Multimodal Model Deep Learning

Advanced Science, EarlyView.
This study introduces AI‐TFNA, an innovative artificial intelligence model designed to assist cytopathologists in classifying thyroid nodules based on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The model effectively differentiates between benign and malignant thyroid nodules, demonstrating significant potential as a screening ...
Yuanzheng Lou, Yongjian Su, Haoda Lu, Wencai Li, Weihua Yin, Shengnan Li, Huobiao Zhu, Kok Haur Ong, Gang Chen, Yong Jiang, Yifei Liu, Shenglei Li, Manchun Yang, Zhengyu Zhang, Xiaoyan Wang, Xiaohui Zhu, Xinmi Huo, Longjie Li, Chao Wang, Nanyan Zhang, Weijun Pan, Bin Shang, Xudan Yang, Yongqiang Zhu, Xiaolin Liu, Weimiao Yu, Xiuwu Bian, Yanqing Ding   +27 more
wiley   +1 more source

Improving policy design and epidemic response using integrated models of economic choice and disease dynamics with behavioral feedback. [PDF]

PLoS Comput Biol
Du H, Zahn MV, Loo SL, Alleman TW, Truelove S, Patenaude B, Gardner LM, Papageorge N, Hill AL.   +8 more
europepmc   +1 more source

CRISPR‐DNA Polymerase Assisted Targeted Mutagenesis for Regulable Laboratory Evolution

Advanced Science, EarlyView.
This study develops an in vivo targeted mutagenesis system based on CRISPR‐guided bacteriophage T5 or T7 DNA polymerases. This system can enable all possible types of substitution mutations within an expanded mutagenesis window in Escherichia coli and exhibit application potential in different microorganisms, thus accelerating the evolution of ...
Shuaili Chen, Xiangdi Chen, Yifan Peng, Qinghua Li, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Guoqiang Zhang   +8 more
wiley   +1 more source

Impacts of DRG point-based payment system on healthcare resource utilization and provider behavior: a pilot quasi-experimental study in China. [PDF]

Front Public Health
Huang X, Zhu J, Zhang J.
europepmc   +1 more source

A Multicenter Validation of a Fully Automated Chemiluminescence Immunoassay for Plasma Elafin in Psoriasis Diagnosis and Severity Assessment

Advanced Science, EarlyView.
The fully automated CLIA demonstrates high sensitivity and specificity for plasma Elafin, achieving 88% diagnostic accuracy and an AUC of 0.92 for psoriasis detection in a multicenter cohort. The assay reliably distinguishes psoriasis from other dermatoses, objectively stratifies disease severity, and allows longitudinal monitoring, supporting its ...
Jingkun Yi, Meng Xu, Ling Han, Zhining Dong, Ruimin Liu, Xiaomei Zhang, Di Hu, Chuanjian Lu, Xiaobo Yu   +8 more
wiley   +1 more source