Results 191 to 200 of about 615,229 (301)

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

open access: yesAdvanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song   +6 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

open access: yesAdvanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha   +2 more
wiley   +1 more source

Smart Bioinspired Material‐Based Actuators: Current Challenges and Prospects

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This work gathers, in a review style, an extensive and comprehensive literature overview on the development of autonomous actuators based on synthetic materials, bringing together valuable knowledge from several studies. Furthermore, the article identifies the fundamental principles of actuation mechanisms and defines key parameters to address the size
Alejandro Palacios   +4 more
wiley   +1 more source

Deep Reinforcement Learning Approaches for Sensor Data Collection by a Swarm of UAVs

open access: yesAdvanced Intelligent Systems, EarlyView.
This article presents four decentralized reinforcement learning algorithms for autonomous data harvesting and investigates how collaboration improves collection efficiency. It also presents strategies to minimize training times by improving model flexibility, enabling algorithms to operate with varying number of agents and sensors.
Thiago de Souza Lamenza   +2 more
wiley   +1 more source

Readiness and implications for adopting digitized payment of community health workers: a qualitative study of Benin and Uganda. [PDF]

open access: yesFront Health Serv
Kabayambi JP   +9 more
europepmc   +1 more source

Bayesian Optimisation for the Experimental Sciences: A Practical Guide to Data‐Efficient Optimisation of Laboratory Workflows

open access: yesAdvanced Intelligent Systems, EarlyView.
This study provides an introduction to Bayesian optimisation targeted for experimentalists. It explains core concepts, surrogate modelling, and acquisition strategies, and addresses common real‐world challenges such as noise, constraints, mixed variables, scalability, and automation.
Chuan He   +2 more
wiley   +1 more source

Lifestyle Medicine and Mitigating the Rising Cost of Healthcare. [PDF]

open access: yesAm J Lifestyle Med
Bettini R   +3 more
europepmc   +1 more source

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