Results 221 to 230 of about 154,598 (309)

Patient‐derived organoid‐immune co‐cultures integrated with multi‐omics reveal immunotherapy resistance mechanisms in urothelial carcinoma

iMeta, EarlyView.
Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the exploration of its role in immune checkpoint inhibitor (ICI) resistance remains scarce, thus impeding a deeper understanding of the tumor immune microenvironment
Shan Jiang, Yuxuan Song, Yun Peng, Ran Yan, Yunze Niu, Baoqiang Chen, Jiaxing Lin, Jilin Wu, Shixiang Wang, Yiqing Du, Caipeng Qin, Yihan Lin, Tao Xu   +12 more
wiley   +1 more source

Assessment of the cytotoxic, proapoptotic, and genotoxic effects of bromelain on human peripheral blood mononuclear cells. [PDF]

Sci Rep
Bernasinska-Slomczewska J, Hikisz P, Pieniazek A.   +2 more
europepmc   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

A new fully closed automated banking process for healthy autologous cells to standardize the starting material for CAR T manufacturing. [PDF]

Mol Ther Adv
Xu Z, Xu Y, Ding W, Chen J, He Y, Chen J, Sun Y, Guo X, Qian Q.   +8 more
europepmc   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

LncRNA as a diagnostic marker for rheumatoid arthritis: a systematic review and meta-analysis. [PDF]

Korean J Intern Med
Luo LL, Chen YT, Xu YN, Lu M, Liu XD.
europepmc   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

SiteCELL enables <i>on-site</i> PBMCs purification and cryopreservation for immune single-cell profiling of underrepresented ancestries. [PDF]

iScience
Espinosa-Jaime A, Zambada-Moreno O, Corona-Gómez JA, de Jesús-Ortega M, Hernandez-Coronado M, Santos Dias BD, Diniz LA, Leaden L, Cebinelli GM, Marchese D, Rojas-Hidalgo A, Vicencio E, Pérez-Stuardo D, Urquiza-Zurich S, Fajardo ME, Colombo A, Donoso G, Méndez T, Gallo C, Guerrero-Cázares H, Robles-Espinoza CD, Possik PA, Barreto G, Spangenberg L, Verdugo RA, Maracaja-Coutinho V, Severino P, Moreno-Estrada A, Ortiz-Ramírez C.   +28 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Enhancing Non-small Cell Lung Cancer Susceptibility to Anti-PD-1/PD-L1 Therapy through PD-L1 Ligand-Ir(III) Complex Conjugates. [PDF]

Cancer Commun (Lond)
Pagliara V, Assoni G, Polcaro G, Bossi A, Penconi M, Liguori L, Seneci P, Di Leva FS, D'Amore VM, Brancaccio D, Santoro F, Ferrone CR, Ciaglia E, Puca AA, Pepe S, Marinelli L, Arosio D, Sabbatino F.   +17 more
europepmc   +1 more source