Results 201 to 210 of about 5,166 (218)

Reduced susceptibility to aztreonam-avibactam conferred by acquired AmpC-type β-lactamases in PBP3-modified Escherichia coli

European Journal of Clinical Microbiology and Infectious Diseases
Carbapenemase-producing Enterobacterales are a growing threat, and very few therapeutic options remain active against those multidrug resistant bacteria. Aztreonam is the molecule of choice against metallo-beta-lactamases (MBL) producers since it is not hydrolyzed by those enzymes, but the co-production of acquired plasmidic cephalosporinases or ...
Nicolas Helsens, Mustafa Sadek, Christophe Le Terrier   +2 more
exaly   +4 more sources

Resistance to ceftazidime in Escherichia coli associated with AcrR, MarR and PBP3 mutations and overexpression of sdiA

Journal of Medical Microbiology, 2014
The mechanisms responsible for the increase in ceftazidime MIC in two Escherichia coli in vitro selected mutants, Caz/20-1 and Caz/20-2, were studied. OmpF loss and overexpression of acrB, acrD and acrF that were associated with acrR and marR mutations and sdiA overexpression, together with mutations A233T and I332V in FtSI (PBP3) resulted in ...
Tavío, María M., Aquili, Virginia D., Vila, Jordi, Poveda, Jose B.   +3 more
openaire   +3 more sources

Global emergence of Escherichia coli with PBP3 insertions

Journal of Antimicrobial Chemotherapy
Abstract Objectives Escherichia coli producing metallo-β-lactamases with penicillin-binding protein 3 (PBP3) insertions have reduced susceptibility to aztreonam–avibactam and cefiderocol. Here, we analysed high-quality E. coli genomes for PBP3 insertions.
Haiyan Long, Feifei Zhao, Yu Feng, Zhiyong Zong   +3 more
openaire   +2 more sources

Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime‐Bound Forms

Journal of Molecular Biology, 2012
Staphylococcus aureus is a widespread Gram-positive opportunistic pathogen, and a methicillin-resistant form (MRSA) is particularly difficult to treat clinically. We have solved two crystal structures of penicillin-binding protein (PBP) 3 (PBP3) from MRSA, the apo form and a complex with the β-lactam antibiotic cefotaxime, and used electrospray mass ...
Hisashi, Yoshida, Fumihiro, Kawai, Eiji, Obayashi, Satoko, Akashi, David I, Roper, Jeremy R H, Tame, Sam-Yong, Park   +6 more
openaire   +2 more sources

[Isolation of beta-lactamase non-producing ampicillin-resistant Haemophilus influenzae (BLNAR) and analysis of its PBP3 gene].

Rinsho byori. The Japanese journal of clinical pathology, 2008
We analyzed the incidence of beta-lactamase non-producing ampicillin-resistance (BLNAR) Haemophilus influenzae in Showa University Hospital from June 2004 to March 2005. The ratio of BLNAR in total H. influenzae isolates was 44.5%. BLNAR accounted for 89.6% of the ampicillin non-susceptible strains displaying a minimal inhibitory concentration(MIC) of ...
Fumihiro, Yamaguchi, Takaaki, Kuroda, Tsutomu, Yasuhara, Rika, Wakuta, Kunihiko, Fukuchi, Kunihide, Gomi   +5 more
openaire   +1 more source

Escherichia coli strains possessing a four amino acid YRIN insertion in PBP3 identified as part of the SIDERO-WT-2014 surveillance study

JAC-Antimicrobial Resistance, 2020
Takafumi Sato, Akinobu Itô, Shuhei Matsumoto   +2 more
exaly  

Multidrug-resistant Escherichia coli mutants selected with diazepam or lomefloxacin overexpressing soxS, sdiA, acrAB, TolC and PBP3

2019
S52
Tavio, M. M., Aquili, V., Fabrega, A., Gonzalez-Lama, Z., Poveda, J. B., Vila, J.   +5 more
openaire   +1 more source

Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of β-Lactam Target-Mediated Resistance

Journal of Molecular Biology, 2019
Dom Bellini, Lizbé Koekemoer, Hector Newman   +2 more
exaly