Results 241 to 250 of about 16,022 (277)

Postnatal Growth Considerations for PBPK Modeling

Journal of Toxicology and Environmental Health, Part A, 2007
A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs ...
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, William, Slikker, John F, Young   +4 more
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PBPK and Toxicokinetic Modeling

2022
Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
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PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY

Journal of Toxicology and Environmental Health, 1997
Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young, W S, Branham, D M, Sheehan, M E, Baker, W D, Wosilait, R H, Luecke   +5 more
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QSARs for PBPK modelling of environmental contaminants

SAR and QSAR in Environmental Research, 2011
Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. However, it is a challenge to determine the chemical-specific parameters for these models, particularly in time- and resource-limiting situations.
T, Peyret, K, Krishnan
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Analysis of PBPK Models for Risk Characterization

Annals of the New York Academy of Sciences, 1999
Abstract: Adoption of a Bayesian framework for risk characterization permits the seamless integration of different kinds of information available in order to choose and parameterize risk models. It also becomes easy to disentangle uncertainty from variability, through hierarchical statistical modeling.
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Windows based general PBPK/PD modeling software

Computers in Biology and Medicine, 2008
A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues.
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, Daniel R, Doerge, William, Slikker, John F, Young   +5 more
openaire   +2 more sources

PBPK modeling of complex hydrocarbon mixtures: gasoline

Environmental Toxicology and Pharmacology, 2004
Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometimes lesser amounts of additives, and often exhibit qualitatively similar pharmacokinetic (PK) and ...
James E, Dennison, Melvin E, Andersen, Ivan D, Dobrev, Moiz M, Mumtaz, Raymond S H, Yang   +4 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

Clinical Pharmacology & Therapeutics, 2012
This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett, O, Della Casa Alberighi, S, Läer, B, Meibohm   +3 more
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PBPK Modeling Advances Understanding of D4 Pharmacokinetics

Toxicological Sciences, 2003
The article highlighted in this issue is Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise, by Micaela B. Reddy, Melvin E. Andersen, Paul E. Morrow, Ivan D. Dobrev, Sudarsanan Varaprath, Kathleen P. Plotzke, and Mark J. Utell (pp. 43-56).
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