Results 201 to 210 of about 386,310 (261)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Single-Cell and Spatial Transcriptomics Uncover Immune Dynamics and Cellular Heterogeneity in Benign Prostatic Hyperplasia and Prostate Cancer Transition. [PDF]

MedComm (2020)
Luo Y, Zhong H, Shang T, Hu B, Yuan D, Jia X, Lin R, Wang Z, Fang Y, Zhu G, Song J, Liu Z, Yan B, Sun F, Jia Z, Yu Y, Mao L, Huang H, Zhu J.   +18 more
europepmc   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Requirement for written informed consent and selection bias in a chart-review prostate cancer study. [PDF]

Am J Epidemiol
Zheng R, Das SK, Tran TD, Friedrich NA, Cummings SM, Gonzalez A, De Hoedt AM, Bellerose H, Hoffmeyer A, Van de Ven TJ, Freedland SJ.   +10 more
europepmc   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Protocatechuic acid and syringin improve cardiac damage and autonomic imbalance caused by dyslipidemia in mice. [PDF]

Front Pharmacol
Jeong M, Kim Y, Kwon H, Hyun KY, Kang DY, Jang A, Ju Y, Choi GE.   +7 more
europepmc   +1 more source

Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2. [PDF]

Cell Commun Signal
Pérez-Gómez JM, Prats-Escribano A, Gil-Duque I, Arroyo-Millán L, Huertas-Cabrera H, Núñez-Santos MA, López-Ruiz DJ, Mata-Ordoñez F, González-Serrano T, Ortea I, Porcel-Pastrana F, Álvarez-Benito M, Planque M, Carrasco-Valiente J, Gómez-Gómez E, Guzmán-Ruiz R, Fuentes-Fayos AC, Fendt SM, Gahete MD, Sarmento-Cabral A, Malagón MDM, Luque RM.   +21 more
europepmc   +1 more source

Systematic Scale-Up of Mechanochemical Paracetamol-Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies. [PDF]

Org Process Res Dev
Schöbel JH, Gopinath D, Felderhoff M.
europepmc   +1 more source

Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review). [PDF]

Mol Med Rep
Song J, Cui H, Yang P, Xu Y, Liu Y, Zhang G, Liu Y, Tian A, Che J, Sun H, Zhang Z.   +10 more
europepmc   +1 more source