Results 271 to 280 of about 896,372 (322)

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Chemometric Methods Applied to Infrared and Raman Spectroscopy for Arboviruses Diagnosis: A Systematic Review With Meta-Analysis. [PDF]

Anal Sci Adv
Domingues KZA, Lazo REL, do Amaral LS, Cobre AF, Ferreira LM, Pontarolo R.   +5 more
europepmc   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Dietary Supplementation with Protocatechuic Acid and a Complex <i>Eucommia ulmoides</i> Leaf Extract Differentially Enhanced Reproductive Performance and Modulated Gut Microbiota in Late-Pregnancy Sows. [PDF]

Animals (Basel)
Tan J, He J, Zhang H, Wu S.
europepmc   +1 more source

Continuous Physics‐Informed Learning Expedited Battery Mechanism Decoupling

Advanced Science, EarlyView.
A battery modeling framework combining dual neural networks with physical prior is presented to track internal mechanisms, decouple overpotential components, and early predict aging trajectories using only DC data, eliminating the need for additional measurements.
Shanling Ji, Jun Yuan, Bojing Zhang, Aleksei Sanin, Leon Merker, Zhisheng Zhang, Jianxiong Zhu, Helge Sören Stein   +7 more
wiley   +1 more source

Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review). [PDF]

Oncol Lett
Chen M, Wang F, Wang W, Feng K, Xiang K, Gong X, Tao Z, Liu W.   +7 more
europepmc   +1 more source

CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover

Advanced Science, EarlyView.
This study identifies CIDEC, an lipid droplet (LD)‐fusion associated protein upregulated by CREBH during early regeneration, as a negative regulator of liver regeneration through its unexpected role in sequestering triglyceride (TG) within LDs. CIDEC depletion reduces LD size, mobilizes LD‐stored TG, enhances TG catabolism and free fatty acid (FFA ...
Feng Ouyang, Yining Li, Zixuan Zhang, Fangfang Sun, Yihong Shi, Qian Gui, Da Luo, Changyong Hu, Hang Su, Kaiqi Shen, Lu Gao, Hui Yang, Feng‐Jung Chen, Rong Li, Tong‐Jin Zhao, Peng Li, Tian‐Shu Yang   +16 more
wiley   +1 more source

Age-related variations in thyroid function hormones indicate the risk of prostate cancer: evidence from a nationally representative dataset. [PDF]

Transl Androl Urol
Chu Y, Zhang D, Feng Y.
europepmc   +1 more source

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Advanced Science, EarlyView.
This study introduces a miniaturized wireless neural recording system integrated with custom‐designed 120‐channel µECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The system can capture and characterize behavior‐specific neural signals, including drinking‐related activation, pre‐vocalization anticipatory responses,
Hongru Liu, Xinyuan Cao, Jiyong Li, Lingyi Zheng, Jingwei Li, Qianbing Li, Min Xie, Huimin Li, Xiaolong Wang, Yuyu Wu, Xiangyu Zhang, Yizheng Wang, Xize Gao, Tiancheng Sheng, Nianzhen Du, Chengao Xu, Kai Zhou, Jing Xu, Changxiang Yan, Lianqing Liu, Lixia Gao, Xinjian Li, Mingjun Zhang   +22 more
wiley   +1 more source

Identification of programmed cell death associated key genes in benign prostatic hyperplasia and prostate cancer development by integrated bioinformatics analysis and machine learning. [PDF]

Transl Androl Urol
Chen J, Chen B, Ning Y, Ran B, Liu L, Cao D.   +5 more
europepmc   +1 more source