Results 81 to 90 of about 1,131,696 (312)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Prioritization of watershed through morphometric parameters: a PCA-based approach

Applied Water Science, 2017
Remote sensing (RS) and Geographic Information Systems (GIS) techniques have become very important these days as they aid planners and decision makers to make effective and correct decisions and designs.
S. G. Meshram, S. Sharma
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Le fait du prince comme cause d’admission au régime de force majeure en droit minier congolais : notion, portée et implications [PDF]

Mouvements et Enjeux Sociaux
La succession d’évènements tragiques au cours des XX et XXIe siècles a mis en évidence l’importance de la gestion des risques avec notamment des risques industriels, financiers, sociétaux (les soulèvements), sanitaires (pandémie de covid-19), ou encore ...
Patrick BONDONGA LESAMBO , Kevin ESHIMATA NGIMBI   +1 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Characterization of Vermillion and Lipstick Using Thin-Layer Chromatography and Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy With Chemometrics

Arab Journal of Forensic Sciences & Forensic Medicine
The study employed Thin Layer Chromatography (TLC) and Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) to analyze local brands of vermillion and lipstick samples.
Aishwarya P. V, Mebin Wilson Thomas, Shalabha P, Unnimaya S, Suchita Rawat   +4 more
doaj   +1 more source

Information-theoretically Optimal Sparse PCA

, 2014
Sparse Principal Component Analysis (PCA) is a dimensionality reduction technique wherein one seeks a low-rank representation of a data matrix with additional sparsity constraints on the obtained representation. We consider two probabilistic formulations
Deshpande, Yash, Montanari, Andrea
core   +1 more source

Fair principal component analysis (PCA): minorization-maximization algorithms for Fair PCA, Fair Robust PCA and Fair Sparse PCA

, 2023
In this paper we propose a new iterative algorithm to solve the fair PCA (FPCA) problem. We start with the max-min fair PCA formulation originally proposed in [1] and derive a simple and efficient iterative algorithm which is based on the minorization-maximization (MM) approach.
Babu, Prabhu, Stoica, Petre
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

HAND HUMAN RECOGNITION BERDASARKAN GEOMETRI TELAPAK TANGAN MENGGUNAKAN PRINCIPAL COMPONENT ANALYSIS

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2019
Sistem pengenalan diri merupakan sebuah sistem yang dapat digunakan untuk mengenali identitas sesorang yang dapat dilakukan secara otomatis menggunakan komputer.
Nurul Fadillah, Imanuddin Imanuddin, Dewi Lestari   +2 more
doaj   +1 more source