Results 111 to 120 of about 476,194 (255)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Pro-neuropeptide Y as a circulating biomarker for poor prognosis in prostate cancer. [PDF]

Sci Rep
Djusberg E, Lundquist K, Lundholm M, Josefsson A, Karlsson CT, Schwenk JM, Brattsand M, Bergh A, Wikström P.   +8 more
europepmc   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

Normalized periprostatic adipose tissue thickness: an imaging marker associated with prostate biopsy outcomes among patients with PI-RADS and PSA double gray zone. [PDF]

Adipocyte
Xiong T, Shen L, Fan Y, Liu Z, Jin S, Wu H, Yang Z, Niu Y.   +7 more
europepmc   +1 more source

Monitoring based on MIC-PCA and SVDD for industrial process

, 2017
Complex industrial processes are often non-linear and non-Gaussian, while the traditional principal component analysis (PCA) method assumes that the data are Gaussian and linear.
Wang ZW(王中伟), Zhou XF(周晓锋), Li S(李帅), Song H(宋宏)   +3 more
core  

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Long-term Outcomes in Men with Stable PSA During 5-α Reductase Inhibitor Therapy After Negative Prostate Biopsy: Population-based Study. [PDF]

Eur Urol Open Sci
Ventimiglia E, Westerberg M, Orasson AW, Ahlberg M, Robinson D, Gedeborg R, Stattin P, Garmo H.   +7 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Bone remodeling: a central mechanism in prostate cancer bone metastasis. [PDF]

PeerJ
Tang H, Chen J, Wu H, Lv Y, Wa Q, He S.
europepmc   +1 more source

Characterization of metabolic alteration patterns in patients with glioma using Scaled Subprofile Modeling – PCA

reservedIl modello di profilo scalato (SSM) è un algoritmo multivariato basato su PCA che identifica le principali fonti di variazione nei dati delle immagini cerebrali di pazienti e gruppi di controllo, mentre respinge componenti di minore importanza ...
FAJRI, JONES
core