Results 261 to 270 of about 244,017 (337)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

PCB RF Probe Landing Pads for mm-Wave Measurements

open access: gold, 2016
Philipp Franz Freidl   +6 more
openalex   +1 more source

Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay

open access: yesDrug Testing and Analysis, EarlyView.
Hair analysis in children from a rural community in Paraguay reveals exposure to organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors, highlighting the urgent need for stricter environmental protections and preventive health measures. ABSTRACT Chronic exposure to pesticides can cause carcinogenic, reproductive,
Stela Benitez Leite   +5 more
wiley   +1 more source

Shock wave propagation characteristics of aluminum‐containing explosive in corrugated steel‐lined tunnel

open access: yesDeep Underground Science and Engineering, EarlyView.
Aluminum‐enhanced afterburning renders AE explosives more hazardous than conventional ones. Corrugated steel linings reduce far‐field AE blast overpressure by ~50% through wave reflection and dissipation. The developed model accurately predicts peak pressure (<10% error) and arrival time (<3% error), supporting protective design.
Zhen Wang   +5 more
wiley   +1 more source

Latent Trajectories of Body Mass Index and Depressive Symptoms in Inpatients With Anorexia Nervosa: Predictors and Outcomes

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Inpatient treatment aimed at weight restoration and psychiatric stabilization is often required for individuals with anorexia nervosa (AN). This study aimed to identify distinct trajectories of change in body mass index (BMI) and depressive symptoms during inpatient treatment, examine clinical predictors and outcomes, and test ...
Matteo Martini   +5 more
wiley   +1 more source

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