Results 61 to 70 of about 100,645 (306)
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
Advanced Science, EarlyView.We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
Deep Sequencing-Based Identification of Small Regulatory RNAs in Synechocystis sp PCC 6803
, 2014 Synechocystis sp. PCC 6803 is a genetically tractable model organism for photosynthesis research. The genome of Synechocystis sp. PCC 6803 consists of a circular chromosome and seven plasmids.
Chen, Hui +4 more
core +1 more source
Advanced Science, EarlyView.We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou +3 more
wiley +1 more source
Enhanced Resistance to UV-B Radiation in Anabaena sp PCC 7120 (Cyanophyceae) by Repeated Exposure
, 2014 In natural habitats, organisms especially phytoplankton are not always continuously subjected to ultraviolet-B radiation (UVBR). By simulation of the natural situation, the N-2-fixing cyanobacterium Anabaena sp.
Li, DH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China. +2 more
core +1 more source
Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
Necesidad de tratamiento ortodóntico en estudiantes de 10 a 12 años. Matanzas
Revista Médica Electrónica, 2013 La detección de las maloclusiones dentarias en edades tempranas evitaría su agravamiento y las consecuencias funcionales, psicosociales y económicas, así como su repercusión en la calidad de vida de muchos individuos.
Aleida de la C Pérez Lauzurique +3 more
doaj
, 2012 A Thesis Submitted In Partial Fulfillment of the Requirements For the Degree of Master of Science-BiologyThe cytochrome bf complex is essential for both photosynthetic and respiratory electron transport in cyanobacteria.
Ranade, Saurabh J.
core
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
A metáfora no discurso do trasgressor
Forma y Función, 2010 A metáfora se materializa nos discursos através de múltiplas regras específicas de aparecimento. Este trabalho tem como objetivo verificar quais são os mecanismos, através dos quais, a metáfora funciona no discurso transgressor.
Jefferson Barbosa de Souza +1 more
doaj +2 more sources
Comportamiento de la oclusión dentaria en pacientes operados de cirugía ortognática
Revista Médica ElectrónicaIntroducción: la cirugía ortognática corrige las alteraciones del componente esquelético en las anomalías dentomaxilofaciales. Estas deformidades provocan deficiente relación de los huesos maxilares, afectando la oclusión dentaria y sus funciones ...
Félix Manuel Blanco Mederos +5 more
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