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Towards safer colorectal surgery worldwide: Outcomes and benchmarks from the ESCP CORREA 2022 audit
Colorectal Disease, Volume 27, Issue 11, November 2025.Abstract Introduction
Benchmarking colorectal surgery outcomes informs quality improvement. The ESCP CORREA 2022 snapshot audit aimed to assess contemporary colorectal resection practices and short‐term outcomes across European countries and beyond. Methods
An international prospective multicentre audit was conducted in which adults undergoing elective 2022 European Society of Coloproctology (ESCP) CORREA Collaborating Group, Ionut Negoi, Gabrielle van Ramhorst, Shaji Sebastian, Gianluca Pellino, Muhammed Elhadi, Audrius Dulskas, Bryar Kadir, James Glasbey, Peter Neary, Ana María Minaya Bravo, James Keatley, Alaa El‐Hussuna, Thomas Pinkney, Sanjay Chaudhry, Laura Magill, Rita Perry, Sue Blackwell, Sanjay Chaudhri, Sharfuddin Chowdhury, Dragomir Dardanov, Caterina Foppa, Gaetano Gallo, Elizabeth Li, Dion Morton, Francesco Pata, Gabrielle van Ramshorst, Beatriz Silva Mendes, Baljit Singh, Erman Aytac, Stephanie Breukink, Pamela Buchwald, Niki Christou, Nir Horesh, Karoline Horisberger, Jim Khan, Laura Koskenvuo, Yurij Košir, Hans Lederhuber, Mostafa Shalaby, Carolynne Vaizey, S. Bilali, S. Ferko, A. Gjata, E. Shehi, J. Shahu, S. Bouaoud, M. Abdoun, K. Bouchenak, H. Saada, A. Ouyahia, M. Rais, E. Seddik, M. Bouaoud, A. Kouicem, N. Yacine, L. Nawel, N. Talbi, A. Tidjane, B. Tabeti, A. Hebbar, I. Lalmi, A. Bouanani, O. Bali, N. Benallel, C. Chwat, G. Lemme, G. Rosato, F. Alexandre, D. Valli, M. Gosselink, D. Daryanani, J. Smit, A. Ponson, Y. Casseres, N. Strugnell, B. D’Souza, S. Badiani, T. Kuany, F. Aigner, M. Mitteregger, S. Uranitsch, C. Allmer, G. Moitzi, E. Wallner, R. Stadler, F. Herbst, I. Iliev, E. Samadov, A. Ibrahimli, M. Saeed, R. Varkey, B. Ebrahim, H. Aljazaf, I. Juma, B. Monami, S. Markiewicz, D. Francart, F. Jehaes, N. Debergh, P. Malvaux, S. Grandjean, J. Stijns, E. Van Eetvelde, T. Van de Winkel, S. Violon, G. van Ramshorst, S. Tavares Sousa Castro, D. Van de Putte, Y. Van Nieuwenhove, P. Pattyn, T. Ivanov, E. Filipov, D. Georgiev, V. Neykov, D. Dardanov, M. Sokolov, S. Maslyankov, S. Toshev, P. Gribnev, A. Koychev, M. Karamanliev, D. Dimitrov, P. Vladova, M. Shoshkova, A. Shanker, M. Slavchev, N. Belev, R. Penkov, B. Atanasov, P. Krastev, I. Yotsov, G. Šantak, N. Gouvas, P. Papatheodorou, K. Konstantinou, G. Kokkinos, A. Stylianou, P. Christensen, R. Balachandran, J. Eriksen, M. Kristensen, S. Ingvarsdóttir, M. Ellebaek, J. Baelum, M. Kjær, P. Cuk, I. Al‐Najami, U. Løve, P. Fink, T. Eliasen, D. Zavrakidis, S. Lynge, L. Sjælland, M. Abdel‐Maboud, S. Mahmoud, H. Abozied, M. Al Sayed, A. Swealem, A. Elshinnawy, A. Amer, M. Ewedah, M. Shalaby, H. Elfeki, A. Sakr, A. Sanad, M. Sadek, K. Abdelwahab, I. Nazif, H. Aboelfarh, B. Refky, M. Shetiwy, I. Metwally, M. Abdelkhalek, M. Zuhdy, M. Omar, A. Safy, M. Alansary, B. Trilling, J. Faucheron, F. Tidadini, L. Audeguy, Q. Chenevas‐Paule, A. Roudier, N. de Angelis, C. Schena, G. Bianchi, N. Christou, A. Fürst, M. Brunner, S. Blümel, V. Schmidt, A. Krappitz, A. Türler, M. Derenbach, W. Lydia, J. Baral, S. Muench, F. Pullig, R. Langbecker, D. Jauch, S. Fichtner‐Feigl, H. Neeff, C. Berlin, L. Matuschik, J. Kleeff, U. Ronellenfitsch, O. Bayram, J. Klose, S. Rieder, D. Korkolis, A. Sarafi, E. Fradelos, G. Kavalieratos, I. Katsoulis, I. Papaconstantinou, M. Konstadoulakis, T. Theodosopoulos, A. Gklavas, D. Politis, T. Petropoulou, A. Polidorou, A. Ioannidis, M. Konstantinidis, S. Konstantinidou, K. Konstantinidis, D. Manatakis, C. Barkolias, D. Balalis, N. Tasis, S. Kapiris, A. Kolinioti, M. Sotiropoulou, M. Psarologos, P. Metaxas, A. Papadopoulos, E. Manioti, O. Mouzakis, D. Broutas, V. Nikolaou, G. Tzovaras, I. Baloyiannis, K. Perivoliotis, I. Mamaloudis, F. Bobou, K. Bouchagier, G. Skroubis, I. Maroulis, F. Mulita, E. Abalov, O. Ioannidis, L. Loutzidou, E. Anestiadou, S. Bitsianis, S. Symeonidis, G. Theodoropoulos, M. Frountzas, S. Volteas, N. Dimitriou, D. Thermou, G. Karantzikos, S. Kympouris, C. Mavrantonis, P. Alexakou, A. Karagouni, N. Boltsis, D. Paradellis, D. Schizas, I. Karavokyros, N. Machairas, A. Syllaios, S. Kykalos, K. Stamou, G. Tsiotos, D. Fanidou, E. Kontis, I. Katsaros, E. Kaouras, L. Katsiaras, P. Manikis, N. Zampitis, A. Marinis, E. Bourmpouteli, M. Merrakos, F. Stefou, B. Banky, P. Ónody, L. Lakatos, Á. Dániel, V. Bencze, A. Fülöp, E. Valsdottir, J. Atladottir, H. Sigurdsson, H. Einarsdottir, P. Moller, A. Saklani, M. Kazi, D. Kearney, D. Petrocz‐Turu, C. O’Reily, S. Martin, R. Kennelly, F. Lecot, I. Reynolds, D. Winter, A. Hanly, S. Arya, D. Hechtl, J. O’Riordan, É. Ryan, J. Mahon, D. Kavanagh, N. Christodoulou, P. Neary, B. Creavin, F. Cooke, P. McCullough, H. Earley, I. Kent, N. Horesh, A. Mansur, M. Kyzer, R. Antebi, R. Tutino, M. Santarelli, D. Visconti, A. Ferguglia, L. Rorato, M. Annecchiarico, G. Argenio, C. Pedrazzani, G. Turri, C. Conti, G. Gecchele, E. De Giulio, N. Bicelli, R. Balestri, M. Puccini, P. Buccianti, R. D’Ischia, D. Pezzati, L. Marano, L. Carbone, L. Verre, F. Roviello, R. Piagnerelli, D. Scala, B. Puppio, P. Maione, G. Marino, B. Scotto, F. Ascari, S. Muratori, I. Roli, V. Tonini, M. Cervellera, L. Sartarelli, A. Lauretta, S. Pollesel, M. Olivieri, C. Belluco, M. Calabrò, A. Muratore, B. Cuzzola, E. Herranz Van Nood, M. De Zuanni, M. Manigrasso, G. De Palma, M. Milone, S. Vertaldi, A. Marello, L. Solaini, A. Luzzi, E. Romairone, S. Carrabetta, P. Grondona, A. Filippelli, G. Moretto, I. Harmony, F. Bianco, S. Gili, A. Novi, S. Grassia, A. Cappiello, N. Tamini, L. Cigagna, F. Ghignone, G. Ugolini, L. Santandrea, S. Bolzon, C. Marafante, E. Moggia, M. Grande, M. Campanelli, L. Siragusa, F. Santori, G. Sica, U. Grossi, R. Galleano, A. Langone, M. Ciciliot, M. Malerba, P. De Nardi, A. Vignali, G. Carbone, R. Rosati, M. Rottoli, A. Belvedere, A. Gori, C. Larotonda, S. Cardelli, T. Violante, D. Sasia, M. Giuffrida, E. Beltrami, G. Preve, S. Armentano, P. Mosangini, M. Ammendola, G. Currò, G. Ammerata, R. Filippo, A. Picciariello, M. De Fazio, L. Vincenti, G. Tomasicchio, F. Selvaggi, G. Pellino, M. D’Ambrosio, F. Menegon Tasselli, D. Massaro, G. Terrosu, G. Calini, L. Bonello, F. Leone, A. Khamees, S. Al‐issawi, S. Abu Wardeh, A. Mansour, A. Mohammad, O. Shattarah, R. Ebbini, O. Sarhan, M. Nour, F. Daoud, A. Tarboush, A. Pcolkins, G. Alkadeeki, F. AlMaadany, A. Kredan, A. Mohamed, A. Haddud, W. Abdulnabi, F. Fauzi, M. Ali, D. Zreeg, W. Aldressi, E. Hosain, H. Alkeelani, I. Abuzeid, A. Alkaseek, H. Shames, H. Baliad Bakeer, F. Elhajdawe, E. Abdulwahed, E. Alshareea, K. Derwish, E. Soula, M. Zagmen, S. Zagmen, A. Fteis, H. Mansour, H. Gholka, A. Dulskas, J. Kuliavas, Z. Gricius, A. Aleinikov, R. Bradunaite, A. Nikolovski, I. Fildishevski, E. Minova, M. Mohamad Salmi, A. Md Nor, F. Elagili, M. Sainal, A. Zainudin, F. Hayati, R. Sriram, S. Subramaniam, J. Mah, S. Tan, A. Zakaria, Z. Zakaria, M. Wong, K. Hamdan, S. Dass, P. Andrejevic, J. Psaila, C. Cini, J. Schembri Higgins, M. Portelli, A. Majbar, A. Souadka, A. Benkabbou, S. Echiguer, M. El Hassouni, J. Konsten, F. Aarts, F. van Osch, T. Schok, E. Boerma, M. Martens, I. Poodt, K. van Dam, I. Bissett, C. Varghese, W. Xu, G. O’Brien, J. Penfold, M. Alvarez, R. He, A. Lin, P. Fagan, S. Farrant, S. Jury, J. Canton, C. Harmston, M. McGuinness, H. 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Martín Ramiro, E. Cagigal Ortega, M. Cancelas Felgueras, E. Colás‐Ruiz, J. Lliteras‐Jorge, M. Tasende‐Presedo, S. Baena‐Bradaschia, L. Lozano‐Salva, J. Gomez‐Rosado, J. Valdes‐Hernandez, F. DelRio‐Lafuente, J. Cintas‐Catena, A. Perez‐Sanchez, J. Abrisqueta, N. Ibáñez, B. Arencibia‐Pérez, C. Roque‐Castellano, E. Nogués‐Ramia, Y. Sosa‐Quesada, M. Artiles‐Armas, S. Gortázar de las Casas, I. Pascual Migueláñez, M. Álvarez Gallego, A. Gegundez Simón, B. Monje Vera, A. Minaya‐Bravo, A. Sanchez‐Gollarte, A. Galvan‐Perez, E. Gonzalez‐Gonzalez, S. Alonso, M. Jiménez, S. Salvans, M. Pascual, B. Montcusí, E. Viejo Martínez, J. Ripolles, M. de Fuenmayor Valera, C. Ortiz Johansson, E. Alvaro Cifuentes, E. Gutiérrez Cafranga, R. Escalera Pérez, W. Sánchez Bautista, J. Esteban Ramos, F. García Molina, L. Cristobal, M. Gomez, C. Cagigas, N. Suarez, G. Valero‐Navarro, E. Pellicer‐Franco, V. Soria‐Aledo, M. Mengual‐Ballester, J. Garcia‐Marin, A. Solís Peña, C. Petrola Chacón, M. Kraft Carré, F. 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Venkatasubramaniam, C. Yao, E. Anand, A. Myers, Y. Mohsen, A. Prabhudesai, A. Slesser, S. Mallappa, G. Bond‐Smith, T. Fung, S. Kok, F. Runau, B. Singh, S. Khan, A. Eltweri, J. Wolff, K. Boyle, P. Sarmah, I. Kais, H. Merriman, S. Gurjar, M. Al‐Ani, N. Ul‐Ain, H. Tabasi, B. Keeler, F. Dixon, M. Rana, J. Khan, R. Harvitkar, S. Stefan, R. Duhoky, R. Bethune, H. Lederhuber, T. Cheung, E. Matthews, K. Altaf, N. Pang, C. Simms, G. Titley‐Wilson, M. Thaha, A. Minicozzi, H. Patel, A. Taha, G. Omar, M. Riad, C. Magee, S. Small, L. Convie, J. Ong, C. Rossborough, N. Chandratreya, J. Noronha, M. Alshibshoubi, E. Dean, J. Thompson +943 morewiley +1 more sourceOrganization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II) [PDF]
, 1993 A complete cDNA encoding the acrosin-trypsin inhibitor, HUSI-II, was used as a probe to isolate genomic clones from a human placenta library. Three clones which cover the entire HUSI-II gene were isolated and characterized.Abelson, Baumann, Beato, Bird, Dynan, Fink, Fink, Greene, Greene, Haendle, Hehlein-Fink, Horii, Kazal, Laskowski, Laskowski, LaThangue, Luerssen, Mead, Moritz, Policastro, Reynolds, Sambrook, Scott, Stein, Strähle, Stühmer, Tan, Tora, Weih +28 morecore +1 more sourceEndothelial‐Mesenchymal Transition in Tumor Microenvironment Promotes Neuroendocrine Differentiation of Prostate Cancer
Cancer Science, Volume 116, Issue 10, Page 2712-2722, October 2025.Endothelial‐mesenchymal transition (EndoMT) contributes to neuroendocrine differentiation (NED) in prostate cancer. Using in vitro co‐culture models, we show that EndoMTed endothelial cells promote NED in prostate cancer cells via GM‐CSF signaling. These findings reveal a previously unrecognized paracrine mechanism by which the tumor microenvironment ...Takumi Kageyama, Manabu Kato, Shiori Miyachi, Xin Bao, Sho Sekito, Yusuke Sugino, Shinichiro Higashi, Takeshi Sasaki, Kouhei Nishikawa, Yasuhiro Murakawa, Masatoshi Watanabe, Takahiro Inoue +11 morewiley +1 more sourceDevelopment and Validation of a Scaffold‐Free Human Multilineage Spheroid Model for Early Stage Cholangiopathies Driven by Cholangiocyte Senescence
Liver International, Volume 45, Issue 10, October 2025.ABSTRACT Background and Aims
Cholangiopathies, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and post‐COVID‐19 cholangiopathy (PCC), involve chronic cholangiocyte injury, senescence, epithelial–stromal crosstalk, and progressive fibrosis.Cheuk‐Ting Wu, Anja Moncsek, Joachim Mertens +2 morewiley +1 more sourcePerioperative administration of fibrinogen does not increase adverse cardiac and thromboembolic events after cardiac surgery [PDF]
, 2017 Background Although infusion of fibrinogen concentrate is increasingly used in bleeding patients after cardiac surgery, safety data are scarce. We aimed to evaluate the effect of perioperative administration of fibrinogen concentrate on postoperative ...Bolliger, D., Fassl, J., Filipovic, M., Hampl, K., Lurati Buse, G., Reuthebuch, O., Seeberger, M. D., Thompson, J. P., Thompson, J. P. +8 morecore Self-assembly and two-dimensional spontaneous resolution of cyano-functionalized [7]helicenes on Cu111 [PDF]
, 2011 Birds of a feather flock together: STM and DFT studies provide the first example of spontaneous chiral resolution of a helicene on a surface. Racemic 6,13-dicyano[7]helicene forms fully segregated domains of pure enantiomers (2D conglomerate) on Cu(111). Boz, Serpil, Diederich, François, Jung, Thomas A., Nguyen, Manh-Thuong, Passerone, Daniele, Pignedoli, Carlo A., Schweizer, W. Bernd, Schär, Michael, Stöhr, Meike, Thilgen, Carlo +9 morecore +2 more sourcesComprehensive genetic analysis of poorly differentiated gastric cancer in young females
Annals of Gastroenterological Surgery, Volume 9, Issue 5, Page 926-932, September 2025.Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim
The reasons behind the Nobuhiro Nakazawa, Takehiko Yokobori, Yohei Morishita, Akinobu Echigo, Reika Kawabata‐Iwakawa, Akiharu Kimura, Akihiko Sano, Makoto Sakai, Ken Shirabe, Hiroshi Saeki +9 morewiley +1 more sourcePaternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications [PDF]
, 2014 The different configurations of maternal and paternal chromatin, acquired during oogenesis and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic genome.Albert, M. (Mareike), Baarends, W.M. (Willy), Baart, E.B. (Esther), Eleveld, C. (C.), Heijden, G.W. (Godfried) van der, Laven, J.S.E. (Joop), Peters, A.H.F.M. (Antoine H. F. M.), Teeuwssen, M. (Miriam), Werken, C. (Christine) van de +8 morecore +2 more sources