Results 41 to 50 of about 4,986 (141)

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +31 more
wiley   +1 more source

Post-COVID-19 Condition Prediction in Hospitalised Cancer Patients: A Machine Learning-Based Approach.

open access: yes
BACKGROUND: The COVID-19 pandemic has led to widespread long-term complications, known as post-COVID conditions (PCC), particularly affecting vulnerable populations such as cancer patients.
Avdeev, S   +28 more
core   +1 more source

An Automated Lab‐On‐A‐Chip Approach for Pollen Tube Growth Manipulation in a Controlled Chemical Environment

open access: yesAdvanced Science, Volume 12, Issue 43, November 20, 2025.
Here, a microfluidic‐based robotic lab‐on‐a‐chip (LoC) device is presented for automated, continuous‐flow investigation and manipulation of single pollen tube growth under precisely controlled chemical gradients. This closed‐loop system streamlines data collection and analysis while enhancing experimental precision compared to manual methods ...
Jiawei Zhu   +10 more
wiley   +1 more source

Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers

open access: yesDrug Testing and Analysis, Volume 17, Issue 11, Page 2220-2227, November 2025.
Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland   +5 more
wiley   +1 more source

Towards safer colorectal surgery worldwide: Outcomes and benchmarks from the ESCP CORREA 2022 audit

open access: yesColorectal Disease, Volume 27, Issue 11, November 2025.
Abstract Introduction Benchmarking colorectal surgery outcomes informs quality improvement. The ESCP CORREA 2022 snapshot audit aimed to assess contemporary colorectal resection practices and short‐term outcomes across European countries and beyond. Methods An international prospective multicentre audit was conducted in which adults undergoing elective
2022 European Society of Coloproctology (ESCP) CORREA Collaborating Group   +943 more
wiley   +1 more source

RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1

open access: yes, 2015
International audienceRalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial ...
Camonis, Jacques   +5 more
core   +1 more source

Endothelial‐Mesenchymal Transition in Tumor Microenvironment Promotes Neuroendocrine Differentiation of Prostate Cancer

open access: yesCancer Science, Volume 116, Issue 10, Page 2712-2722, October 2025.
Endothelial‐mesenchymal transition (EndoMT) contributes to neuroendocrine differentiation (NED) in prostate cancer. Using in vitro co‐culture models, we show that EndoMTed endothelial cells promote NED in prostate cancer cells via GM‐CSF signaling. These findings reveal a previously unrecognized paracrine mechanism by which the tumor microenvironment ...
Takumi Kageyama   +11 more
wiley   +1 more source

ANTIBACTERIAL ACTIVITY OF A SECONDARY METABOLITE-PRODUCING CORAL BACTERIUM Pseudoalteromonas SPECIES [PDF]

open access: yes, 2004
A bacterium, collected at the surface of coral Acropora sp., TAB4.2 was successfully screened for secondary metabolites production based on PCR amplification of the non-ribosomal peptide synthetase gene.
Karna Radjasa, Okky   +5 more
core  

Lossless Encoding of Time-Aggregated Neuromorphic Vision Sensor Data Based on Point-Cloud Compression [PDF]

open access: yes
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Neuromorphic ...
Khan, Nabeel   +5 more
core   +1 more source

Development and Validation of a Scaffold‐Free Human Multilineage Spheroid Model for Early Stage Cholangiopathies Driven by Cholangiocyte Senescence

open access: yesLiver International, Volume 45, Issue 10, October 2025.
ABSTRACT Background and Aims Cholangiopathies, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and post‐COVID‐19 cholangiopathy (PCC), involve chronic cholangiocyte injury, senescence, epithelial–stromal crosstalk, and progressive fibrosis.
Cheuk‐Ting Wu   +2 more
wiley   +1 more source

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