Results 191 to 200 of about 33,716 (264)

Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude‐Integrated EEG in Transported Newborn Infants with Hypoxic–Ischaemic Encephalopathy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To investigate whether early lactate dehydrogenase (LDH) and amplitude‐integrated electroencephalography (aEEG) improve the prediction of outcome in outborn infants transported for therapeutic hypothermia. Method Secondary analysis of a randomised controlled trial (2016–2019) including 113 asphyxiated newborn infants randomised to ...
Hang T. T. Tran, Ha T. Le, Dien M. Tran, Tobias Alfvén, Linus Olson, Lena Hellstrom‐Westas   +5 more
wiley   +1 more source

Semi-Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lau C, van Kesteren C, Smeenk RM, Beex-Oosterhuis MM, Koch BCP, Chan LN, Lin YS, van Rongen A, Knibbe CAJ, Huitema ADR, Huisman-Siebinga H.   +10 more
europepmc   +1 more source

Latent Poisson count models for action count data from technology‐enhanced assessments

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Recent advances in computerized assessments have enabled the use of innovative item formats (e.g., drag‐and‐drop, scenario‐based), necessitating a flexible model that can capture systematic influence of item types on action counts. In this study, we present a refinement scheme that can explicitly model common features of items and allows ...
Gregory Arbet, Hyeon‐Ah Kang
wiley   +1 more source

Deep Eutectic Solvents as Designer Phase-Change Materials for Organic Rankine Cycle Applications. [PDF]

ACS Omega
González J, Cruz P, Hernández R, Llovell F, Garrido JM, Quinteros-Lama H.   +5 more
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

An Automated Fluorescence Microscopy-Based Sensing System for Continuous Detection of Airborne Asbestos Fibers on a PM_2.5 Monitoring Platform. [PDF]

Sensors (Basel)
Kuroda A, Kaga K, Nishimura T, Ichikawa K, Yamazaki S, Funabashi H, Ikeda T, Ishida T.   +7 more
europepmc   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Invasive Giant Goldenrod (<i>Solidago gigantea</i> Aiton): Phytochemical Profiling and Evaluation of Chemopreventive and Antimicrobial Activities. [PDF]

Molecules
Gębarowska E, Wiatrak B, Pachura-Hanusek N, Budek K, Gębarowska M, Gębarowski T.   +5 more
europepmc   +1 more source

Synthesis of 4-Hydroxyphenylamino-Naphthoquinones as Paracetamol-Inspired Analogs: Chemical, In Silico, and Phenotypic Pharmacological Evaluation. [PDF]

Pharmaceutics
Quispe-Díaz IM, Rebaza-Rioja O, Lopez-Mercado S, Enriquez-Lara C, Asunción-Alvarez D, Ybañez-Julca RO, Mantilla-Rodríguez E, Gutiérrez-Alvarado WO, Pino-Rios R, Valderrama JA, Benites J.   +10 more
europepmc   +1 more source

Sustainable Remediation of Pharmaceuticals Using Crop-Residue-Derived Carbons: Bridging Multi-Component Adsorption and DFT Perspectives. [PDF]

Molecules
Kurtebayeva AA, Álvarez-Torrellas S, García J, Gomes HT, Garrido-Zoido JM, Gil MV, Orynbayev SA, Kalmakhanova MS.   +7 more
europepmc   +1 more source