Results 1 to 10 of about 31,095 (106)

Translational aspects of the novel object recognition task in rats abstinent following sub-chronic treatment with phencyclidine (PCP): effects of modafinil and relevance to cognitive deficits in schizophrenia? [PDF]

Frontiers in Psychiatry, 2010
Phencyclidine (PCP) induces a behavioural syndrome in rodents that bears remarkable similarities to some of the core symptoms observed in schizophrenic patients, among those cognitive deficits.
John P Redrobe, Sascha eBull, Niels ePlath   +2 more
doaj   +3 more sources

Effects of Long-term antipsychotic treatment on enkephalin-immunoreactive neurons in rats perinatally treated with phencyclidine [PDF]

Medicinski Podmladak, 2023
Introduction: Schizophrenia is a chronic mental illness that affects 1% of the world's population. The phencyclidine animal model of schizophrenia is based on the glutamate theory of the development of schizophrenia.
Kompanijec Anja, Korica Bojan, Stojković Tihomir   +2 more
doaj   +1 more source

Theabrownin and Poria cocos Polysaccharide Improve Lipid Metabolism via Modulation of Bile Acid and Fatty Acid Metabolism

Frontiers in Pharmacology, 2022
Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide, while no pharmaceutical treatment has been approved. Natural herbs are promising for their amelioration effect on lipid metabolism.
Jieyi Wang, Dan Zheng, Fengjie Huang, Aihua Zhao, Junliang Kuang, Zhenxing Ren, Tianlu Chen, Jing Lei, Jingchao Lin, Xiaoning Wang, Wei Jia, Wei Jia, Guoxiang Xie, Guoxiang Xie, Xiaojiao Zheng   +14 more
doaj   +1 more source

On π-electron conjugation in the five-membered ring of fluoranthene-type benzenoid hydrocarbons [PDF]

Journal of the Serbian Chemical Society, 2009
A fluoranthene-type benzenoid hydrocarbon (FTBH) is a polycyclic conjugated system obtained by joining two ordinary benzenoid hydrocarbons so as to form a five-membered ring.
Gutman Ivan, Đurđević Jelena
doaj   +1 more source

Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine. [PDF]

PLoS ONE, 2010
Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans.
Yoko Hagino, Shinya Kasai, Wenhua Han, Hideko Yamamoto, Toshitaka Nabeshima, Masayoshi Mishina, Kazutaka Ikeda   +6 more
doaj   +1 more source

The Effect of Poria cocos Polysaccharide PCP-1C on M1 Macrophage Polarization via the Notch Signaling Pathway

Molecules, 2023
The homogeneous galactoglucan PCP-1C extracted from Poria cocos sclerotium has multiple biological activities. The present study demonstrated the effect of PCP-1C on the polarization of RAW 264.7 macrophages and the underlying molecular mechanism ...
Xuerui Hu, Bangzhen Hong, Xiaoxiao Shan, Yue Cheng, Daiyin Peng, Rongfeng Hu, Lei Wang, Weidong Chen   +7 more
doaj   +1 more source

Verifying the PCP-rule by five-center bond indices [PDF]

Journal of the Serbian Chemical Society, 2009
According to the recently discovered PCP-rule, the (stabilizing) energy-effect of the cyclic conjugation in the 5-membered ring of acenaphthylene- and fluoranthene-type polycyclic conjugated hydrocarbons increases with the number of phenyl ...
JELENA ĐURĐEVIĆ, IVAN GUTMAN, ROBERT PONEC   +2 more
doaj   +3 more sources

Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice.

PLoS ONE, 2021
In the present study, we evaluated adjuvant potential of Poria cocos polysaccharide (PCP) on the Th1-type immune responses of C57/BL6 mice against ovalbumin (OVA).
Xiaoxiao Dong, Boye Li, Boyang Yu, Tian Chen, Qin Hu, Bo Peng, Wang Sheng   +6 more
doaj   +1 more source

The Long-Term Effects of a Housing First Intervention on Primary Care and Non-Primary Care Physician Visits Among Homeless Adults with Mental Illness: A 7-Year RCT Follow-Up

Journal of Primary Care & Community Health, 2021
Background: Housing First (HF)-based interventions have been implemented in North America and beyond to help people exit homelessness. The effect of these interventions on access to primary and specialist care services is not well-defined.
Cilia Mejia-Lancheros, James Lachaud, Matthew J. To, Patsy Lee, Rosane Nisenbaum, Patricia O’Campo, Vicky Stergiopoulos, Stephen W. Hwang   +7 more
doaj   +1 more source

Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in Apc Min/+ mice

Chinese Medicine, 2022
Background As a first-line chemotherapeutic agent, 5-fluorouracil (5-FU) exhibits many side effects, weakening its efficacy in cancer treatment. In this study, we hypothesize that Poria cocos polysaccharides (PCP), a traditional Chinese herbal medicine ...
Lin Yin, Guoxin Huang, Imran Khan, Lu Su, Wenrui Xia, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Qiang Wu, Jingyi Wang, Wai Kit Leong, W. L. Wendy Hsiao   +10 more
doaj   +1 more source