Results 101 to 110 of about 6,118 (191)

Artificial Intelligence-Driven Electrocardiogram Screening for Asymptomatic Left Ventricular Systolic Dysfunction in the General Population. [PDF]

JACC Adv
Rhee TM, Kang S, Lee MS, Han GI, Yoo AH, Jang JH, Jo YY, Son JM, Kwon JM, Choi SY, Lee HS, Lee H.   +11 more
europepmc   +1 more source

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae. [PDF]

Microb Cell Fact
Dillen J, Eilers T, Dricot CEMK, Van Hee M, Vandenheuvel D, Masschelein J, Lebeer S.   +6 more
europepmc   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling. [PDF]

Development
Jarysta A, Nemelka J, Ramanathan M, Goodrich EJ, Vonderhaar BL, Park S, Orlandi C, Deans MR, Tarchini B.   +8 more
europepmc   +1 more source

Setting up mother–infant pair lactation studies with biobanking for research according to regulatory requirements

British Journal of Clinical Pharmacology, EarlyView.
Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson, Ida Björkgren, Jenny Svedenkrans, Helena Backman, Jarl Hellman, Linda Englund‐Ögge, Mikaela Magnusson, Inger Lindström, Andrea Wutte, Erica Sundell, Pawel Baranczewski, Laura Shaughnessy   +11 more
wiley   +1 more source

Training Primary Care Practitioners In Dermoscopy Diagnostic Algorithms Enhances Diagnostic Accuracy and Triage of Suspected Skin Cancer: Scoping Review Evidence. [PDF]

Dermatol Pract Concept
Ladet A, Lawton S, Boffa MJ.
europepmc   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Proteome-wide quantification of inositol pyrophosphate-protein interactions. [PDF]

Nat Commun
Richter A, Isern JA, Ruwolt M, Lampe S, Majumdar A, Liu F, Furkert D, Fiedler D.   +7 more
europepmc   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source