Communications BiologyProprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the major regulators of low-density lipoprotein receptor (LDLR). Information on role and regulation of PCSK9 in lung is very limited.
Aram Ghalali +6 more
doaj +1 more source
Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase [PDF]
, 2006 Brendan Bingham +11 more
openalex +1 more source
Targeting PCSK9 to tackle cardiovascular disease.
Pharmacology and Therapeutics, 2023 Sandra Hummelgaard +4 more
semanticscholar +1 more source
The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol
Global Cardiology Science and Practice, 2015 [first paragraph of article]A large number of clinical trials over the last 30 years have firmly consolidated the importance of lowering low density lipoprotein cholesterol (LDLc) in the prevention of cardiovascular diseases (CVD) and its associated devastating sequelae.
openaire +4 more sources
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment
European Journal of Clinical Investigation, EarlyView.Inflammation in atherosclerotic cardiovascular disease. Residual inflammatory risk (RIR), defined by high‐sensitive C‐reactive protein (hsCRP) concentration of ≥2 mg/L, represents a strong predictor of future atherosclerotic cardiovascular disease (ASCVD) events. Although increased hsCRP values ≥2 mg/L might be detected in every three out of five ASCVD
Natalie Arnold, Wolfgang Koenig
wiley +1 more source
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis [PDF]
, 2007 Yuewei Qian +16 more
openalex +1 more source
Journal of the American Geriatrics Society, EarlyView.ABSTRACT The risk of atherosclerotic cardiovascular disease increases with advancing age. Elevated LDL‐cholesterol and non‐HDL‐cholesterol levels remain predictive of incident atherosclerotic cardiovascular events among individuals older than 75 years.
Vera Bittner +8 more
wiley +1 more source
The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain [PDF]
, 2007 Eric Hampton +5 more
openalex +1 more source
Catalytic Activity Is Not Required for Secreted PCSK9 to Reduce Low Density Lipoprotein Receptors in HepG2 Cells [PDF]
, 2007 Markey McNutt +2 more
openalex +1 more source
Interactions Between Hepatitis C Virus and Proprotein Convertase Subtilisin/Kexin Type 9 [PDF]
, 2018 Hepatitis C virus (HCV) is a small enveloped positive-sense single-stranded RNA virus that infects 2-3% of the world population. The majority of infected people develop chronic hepatitis, which results in severe liver damages.
Li, Zhubing
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