The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors on Nonfasting Remnant Cholesterol in a Real World Population [PDF]
, 2018 Background. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant effects on low-density lipoprotein (LDL) cholesterol and nonhigh density lipoprotein (HDL) cholesterol. To date, there have been limited reports on
Holmes, Sari D +3 more
core +1 more source
A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake [PDF]
, 2010 Ni Yan +24 more
openalex +1 more source
NUPR1 Promotes Radioresistance in Colorectal Cancer Cells by Inhibiting Ferroptosis
Journal of Cellular and Molecular Medicine, Volume 29, Issue 7, April 2025.ABSTRACT Radioresistance is a major clinical challenge and the underlying mechanism has not been thoroughly elucidated. In this study, a radioresistant (RR) cell line is established to explore the transcriptomic signatures of radioresistance in colorectal cancer (CRC).
Yimin Fang +11 more
wiley +1 more source
Severe Hypercholesterolemia in Four British Families With the D374Y Mutation in the PCSK9 Gene
, 2005 R.P. Naoumova +7 more
openalex +1 more source
PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates [PDF]
, 2011 Marie Lindholm +9 more
openalex +1 more source
Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk
Liver International, Volume 45, Issue 4, April 2025.ABSTRACT Aims Since its discovery, the patatin‐like phospholipase domain containing 3 (PNPLA3) (rs738409 C>G p.I148M) variant has been studied extensively to unravel its molecular function. Although several studies proved a causal relationship between the PNPLA3 I148M variant and MASLD development and particularly fibrosis, the pathological mechanisms ...
Maria Castanho Martins +5 more
wiley +1 more source
Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro [PDF]
, 2011 Soo Ching Chong +3 more
openalex +1 more source
Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy [PDF]
, 2012 Jaroslav A. Hubáček +8 more
openalex +1 more source
PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling [PDF]
, 2012 Kai Kysenius +4 more
openalex +1 more source