Results 291 to 300 of about 40,773 (330)

Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): safety, efficacy, and exploratory biomarker analysis. [PDF]

J Immunother Cancer
Wood C, Lyniv L, Isaacs JM, Kaufman JM, Oduah EI, Clarke J, Crawford J, Stinchcombe T, Tong BC, Wang X, Gu L, Wigle D, Dragnev KH, Antonia SJ, Weinhold K, Ready N.   +15 more
europepmc   +1 more source

Mendelian randomization-based observational cohort study on drug targets: Impact of antihypertensive and lipid-lowering therapies on inflammatory cytokines. [PDF]

Medicine (Baltimore)
Xin J, Xu Z, Zhang F, Sun Y, Wang X, Wu C, Zhao L.   +6 more
europepmc   +1 more source

The Emerging Role of PCSK9 in the Pathogenesis of Alzheimer's Disease: A Possible Target for the Disease Treatment. [PDF]

Int J Mol Sci
Testa G, Giannelli S, Staurenghi E, Cecci R, Floro L, Gamba P, Sottero B, Leonarduzzi G.   +7 more
europepmc   +1 more source

Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations. [PDF]

Diabetes
Rosoff DB, Wagner J, Jung J, Pacher P, Christodoulides C, Davey Smith G, Ray D, Lohoff FW.   +7 more
europepmc   +1 more source

Evaluating the effect of the antiPCSK9 vaccine on systemic inflammation and oxidative stress in an experimental mouse model. [PDF]

Cardiol J
Momtazi-Borojeni AA, Banach M, Sahebkar A.   +2 more
europepmc   +1 more source

Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases. [PDF]

Nat Commun
O'Donnell CW, Farelli JD, Belaghzal H, Chen J, Beech L, Sullivan J, Morrison-Smith C, Siecinski S, Katz A, Mildrum S, Gurnani M, Dhanania P, Webb CR, Castello Coatti G, Rumale P, Costa DFG, Gibson MI, Wang YE, Newman JV, McCauley TG.   +19 more
europepmc   +1 more source

Achieving More Optimal Lipid Control with Non-Statin Lipid Lowering Therapy. [PDF]

Curr Atheroscler Rep
Nicholls SJ, Nelson AJ.
europepmc   +1 more source

Modified pegRNAs mitigate scaffold-derived prime editing by-products. [PDF]

Nat Commun
Antoniou P, Dacquay L, Mårtensson H, Madeyski-Bengtson K, Loyd AL, Shiriaeva A, Gordon E, Mustfa S, Thom G, Hsieh PP, Šviković S, Firth M, Akrap N, Maresca M, Peterka M.   +14 more
europepmc   +1 more source

Aurantio-obtusin improves obesity and protects hepatic inflammation by rescuing mitochondrial damage in overwhelmed brown adipose tissue. [PDF]

Chin Med
Wu R, Liu R, Chen R, Li Y, Xue X, Zhang Y, Li F, Qu J, Qin L, Wang C, Li X.   +10 more
europepmc   +1 more source

Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study. [PDF]

Circ Genom Precis Med
Gagnon E, Gill D, Chabot D, Cronjé HT, Yuan S, Brennan S, Thériault S, Burgess S, Arsenault BJ, Dib MJ.   +9 more
europepmc   +1 more source