Results 271 to 280 of about 1,895,251 (293)

PD-1/PD-L1 in cardiovascular disease

Clinica Chimica Acta, 2020
The PD-1/PD-L1 coinhibitory pathway has critical roles in the immune response and autoimmunity via the regulation of T cell activity. Excessive activity and high expression of this pathway suppresses the function of T cells and immunity. Recent research has indicated that tumour cells express high levels of PD-L1, which has an immunosuppressive effect ...
YunFeng, Sun, Liang, Li, YaWei, Wu, KePing, Yang   +3 more
openaire   +2 more sources

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2022
?????????????????????? ???????????????????????????? ???????????????????? ???????????????????? ?????????????? ?????????????????????????????????? ?????????????? ???????????????????? ?????????????????????????? ???? ???????????? ?????? Pd- ?? Pd-Au ???? ?????????????????????????? (??????) ?? ?????????????????????? (??????) ???????????????? ?????????? ?? ???
openaire   +1 more source

Photoinduced Face-Inversion of Conjugated Tetraene Ligands on a Pd−Pd−Pd Moiety

Journal of the American Chemical Society, 2002
The linear sandwich tripalladium complexes [Pd3{Ar(CH=CH)4Ar}2[BArf]2 (Ar = Ph, p-t-Bu-C6H4, p-styryl-C6H4) undergo photoinduced isomerization involving face-inversion of the tetraene ligands. Irradiation of these complexes with visible light (>510 nm) resulted in rac (staggered sandwich) to meso (eclipsed sandwich) isomerization. The structures of rac
T. Murahashi, Y. Higuchi, T. Katoh, H. Kurosawa   +3 more
openaire   +2 more sources

In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391

Diagnostic Microbiology and Infectious Disease, 1991
Three new aminopyrrolidine-substituted fluorocyclopropyl quinolones--PD 117596, PD 124816, and PD 127391--were tested for in vitro antibacterial activity against 349 bacterial strains, which are primarily clinical isolates. The minimum inhibitory concentrations (MIC) in micrograms/ml required for greater than or equal to 90% of strains were 0.03-0.06 ...
M A, Cohen, M D, Huband, G B, Mailloux, S L, Yoder, G E, Roland, C L, Heifetz   +5 more
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Synthesis and structure of a novel Pd(0)–Pd(IV)–Pd(IV)–Pd(0) mixed-valence complex

Inorganic Chemistry Communications, 2004
Abstract The interaction of PdCl2(PhCN)2 with 1,2-[PhP(H)CH2CH2CH2P(Ph)CH2]2C6H4, generated in situ from the reduction of the corresponding phosphine oxide with LiAlH4 in the presence of Me3SiCl, gave a complex mixture, from which a di- and a tetra-nuclear palladium complex 1 and 2 whose solid state structures were ascertained by X-ray ...
Wong, WT, Yung, KF, Yung, MY, Guo, JP, Wong, WK, Edwards, PG, Liang, H   +6 more
openaire   +3 more sources

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2007
Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice were generated and immunized to induce experimental autoimmune encephalomyelitis (EAE).
Laura L, Carter, Michael W, Leach, Mihai L, Azoitei, Junqing, Cui, Jeffrey W, Pelker, Jason, Jussif, Steve, Benoit, Gretchen, Ireland, Deborah, Luxenberg, G Roger, Askew, Kim L, Milarski, Christopher, Groves, Tom, Brown, Brenda A, Carito, Karen, Percival, Beatriz M, Carreno, Mary, Collins, Suzana, Marusic   +17 more
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The PD-1/PD-L1 Pathway in Human Pathology

Current Molecular Medicine, 2012
T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology.
M. Saresella, V. Rainone, N. M. Al Daghri, M.S. Clerici, D.L. Trabattoni   +4 more
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Registration of PD 20170034, PD 20170044, PD 20170057, and PD 20170060 germplasm lines of cotton

Journal of Plant Registrations
Abstract PD 20170034 (Reg. no. GP‐1163, PI 708129), PD 20170044 (Reg. no. GP‐1164, PI 708130), PD 20170057 (Reg. no. GP‐1165, PI 708131), and PD 20170060 (Reg. no. GP‐1166, PI 708132) are noncommercial breeding lines of upland cotton ( Gossypium hirsutum L.) jointly released
B. T. Campbell, L. L. Hinze, A. L. Thompson, M. A. Jones, D. C. Jones   +4 more
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[PD-L1 expression and PD-1/PD-L1 inhibitors in breast cancer].

Bulletin du cancer, 2018
The development of immune checkpoints inhibitors represents one of the major recent advances in oncology. Monoclonal antibodies directed against the programmed cell death protein 1 (PD-1) or its ligand (PD-L1) provides durable disease control, particularly in melanoma, lung, kidney, bladder and head and neck cancers.
Monneur, Audrey, Goncalves, Anthony, Bertucci, Francois   +2 more
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PD or not PD? That is the question

American Journal of Kidney Diseases, 1997
MAIORCA, Rosario, CANCARINI, Giovanni, OREOPOULOS DG   +2 more
openaire   +2 more sources