Results 141 to 150 of about 18,311 (150)

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy.

European Heart Journal, 2021
AIMS Cardiac immune-related adverse events (irAEs) from immune checkpoint inhibition (ICI) targeting programmed death 1 (PD1) are of growing concern. Once cardiac irAEs become clinically manifest, fatality rates are high.
L. Michel, I. Helfrich, U. Hendgen-Cotta, R. Mincu, S. Korste, S. Mrotzek, A. Spomer, A. Odersky, C. Rischpler, K. Herrmann, L. Umutlu, C. Coman, R. Ahrends, A. Sickmann, Stefanie Löffek, E. Livingstone, S. Ugurel, L. Zimmer, M. Gunzer, D. Schadendorf, M. Totzeck, T. Rassaf   +21 more
semanticscholar   +1 more source

Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

Nature reviews. Immunology, 2023
K. Chamoto, T. Yaguchi, M. Tajima, Tasuku Honjo   +3 more
semanticscholar   +1 more source

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

Nature Medicine, 2021
A. Bassez, H. Vos, Laurien Van Dyck, G. Floris, I. Arijs, C. Desmedt, B. Boeckx, M. Vanden Bempt, I. Nevelsteen, K. Lambein, K. Punie, P. Neven, Abhishek D Garg, H. Wildiers, J. Qian, A. Smeets, D. Lambrechts   +16 more
semanticscholar   +1 more source

Immuno-oncology clinical trials take a turn beyond PD1/PDL1 inhibitors

Nature reviews. Drug discovery, 2023
Ana Rosa Sáez-Ibáñez, Samik Upadhaya, Jay Campbell   +2 more
semanticscholar   +1 more source

Challenges and opportunities in the PD1/PDL1 inhibitor clinical trial landscape

Nature reviews. Drug discovery, 2022
Samik Upadhaya, Svetoslav T. Neftelinov, J. Hodge, Jay Campbell   +3 more
semanticscholar   +1 more source

PD1 blockade improves survival and CD8+ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice

Nature Aging
Korbyn J. V. Dahlquist, M. Huggins, Matthew J. Yousefzadeh, Carolina Soto-Palma, Stephanie H. Cholensky, Mark J. Pierson, Declan M Smith, Sara E. Hamilton, Christina D. Camell   +8 more
semanticscholar   +1 more source

Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy

Nature Immunology, 2022
Giselle M. Boukhaled, Ramy Gadalla, Heidi J. Elsaesser, Diala Abd-Rabbo, R. Quevedo, S. C. Yang, Mengdi Guo, Ben X Wang, B. Noamani, D. Gray, S. Lau, Kirsty Taylor, K. Aung, A. Spreafico, A. Hansen, S. Saibil, N. Hirano, C. Guidos, Trevor J Pugh, T. McGaha, P. Ohashi, A. Sacher, M. Butler, D. Brooks   +23 more
semanticscholar   +1 more source

The diverse functions of the PD1 inhibitory pathway

Nature reviews. Immunology, 2017
A. Sharpe, Kristen E. Pauken
semanticscholar   +1 more source