Results 261 to 270 of about 326,099 (315)

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Repertoire-scale antibody structural prediction informs therapeutic design. [PDF]

Sci Adv
Sang Z, Xiang Y, Huang W, Sargunas PR, Kim YJJ, Feng Z, Taylor DJ, Shi Y.   +7 more
europepmc   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

PDBTools.jl: A Lightweight and High-Performance Julia Package for Molecular Structure File Handling and Analysis. [PDF]

J Chem Inf Model
Martínez L, Lima ABB.
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Discovery of <i>Caralluma</i>-derived pregnane glycosides as potent and selective cholinesterase inhibitors: integrated <i>in silico</i> and <i>in vitro</i> evaluation. [PDF]

RSC Adv
Al-Karmalawy AA, Attia MI, Alnajjar R, El-Shiekh RA, Al Khatib AO, Yousef TA, Abdel-Sattar E.   +6 more
europepmc   +1 more source

SuAVE-Scatter: A Module for Integrating Simulations and SAXS/SANS Analyses. [PDF]

J Chem Inf Model
Caetano DLZ, do Espirito Santo AA, Lima D, Santos DES, Soares TA.   +4 more
europepmc   +1 more source

Molecular mechanism of calcium permeability and magnesium block in NMDA receptors. [PDF]

Nat Neurosci
Steigerwald R, Epstein M, Chou TH, Simorowski N, Furukawa H.   +4 more
europepmc   +1 more source

Affinity purification contaminants identified by cryo-EM and mass spectrometry. [PDF]

Biosci Rep
Belcher ER, Hardwick SW, Maia de Oliveira T, Hyvönen M.   +3 more
europepmc   +1 more source