Results 101 to 110 of about 2,300 (225)

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Optimization of Hydraulic Structure of Rotary Cutting PDC Bit

Shiyou jixie, 2020
Few researches have been conducted on the hydraulic structure optimization design of rotary cutting PDC bit. Standard k-ε model and discrete phase model (DPM) are used to simulate the bottom hole flow field of rotary cutting PDC bit and optimize the ...
Cao Yang, Zhang Boyu
doaj  

Interobserver variability of histopathological assessment in pT1 colorectal carcinoma

Histopathology, Volume 88, Issue 4, Page 868-880, March 2026.
Interobserver variability among 20 gastrointestinal pathologists was evaluated on 80 pT1 colorectal carcinoma cases. A pilot phase was followed by a consensus meeting, then a larger concordance study was performed. High interobserver agreement was achieved after consensus for histological grade, lymphovascular invasion, tumour budding, poorly ...
Karmele Saez de Gordoa, María Daca‐Alvarez, Maite Rodrigo‐Calvo, Ivan Archilla, Sandra Lopez‐Prades, Jose Javier Aguirre, Lorena Alarcón‐Molero, María Cámara Jurado, Adriana Canosa, Francisco Giner, Carmen González‐Lois, Mireya Jimeno, Ismael Jurado, Isidro Machado, Carolina Martínez‐Ciarpaglini, Eva Musulen, Dolores Naranjo, Natalia Papaleo, Cristina Peña, Òria Rosiñol, Rosario Sánchez‐Yuste, Greissy Tibisay Vázquez Benítez, María Pellisé, Miriam Cuatrecasas, on behalf of the EpiT1 Consortium   +24 more
wiley   +1 more source

Community Inventor Days:Scaffolding Grassroots Innovation with Maker Events [PDF]

, 2017
This paper describes a series of Inventor Days designed to catalyse sustainable relationships between communities and makers to support grassroots innovation. By appropriating core properties of hackathons, the Inventor Days brought together residents in
Anderson Chris, Briscoe Gerard, Lodato Thomas James, Townsend Anthony M.   +3 more
core   +3 more sources

Study on geometry and kinematics of spherical single-roller PDC bit

Advances in Mechanical Engineering, 2016
A spherical single-roller bit based on polycrystalline diamond compact (PDC) cutters is designed for the purposes of improving the adaptability of single-roller bit to the stratum with high hardness and abrasiveness.
Chunyan Kong, Zheng Liang, Derong Zhang, Shili Chang   +3 more
doaj   +1 more source

Буровой инструмент, оснащенный термостойкими режущими вставками [PDF]

, 2007
Подано результати дослідження роботоздатності бурового долота, оснащеного АТП складу алмаз – (SiC + СrВ2). Встановлено, що зносостійкість цих пластин не змінюється при їх нагріванні в муфельній печі до 1100 ºС.
Бондаренко, Н. А., Гажа, Г. П., Мечник, В. А., Осипов, А. С., Петруша, И. А.   +4 more
core  

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou, Shuyu Shao, Danning Yang, Ziyan Cheng, Toshihiro Tanaka, Patrick S. C. Leung, Koichi Tsuneyama, Aftab A. Ansari, William M. Ridgway, Pietro Invernizzi, Christopher L. Bowlus, M. Eric Gershwin, Weici Zhang   +12 more
wiley   +1 more source

Study on Flow Field Characteristics of Rotary Cutting PDC Bit Based on DPM Model

Shiyou jixie, 2021
In order to solve the problems of rotary cutting PDC bit such as uneven distribution of hydraulic energy, easy deposition of cuttings, chaotic flow traces and eddy current in returning area, the discrete phase particle model in numerical simulation was ...
Li Jin, Bian Chenyang, Liu Zhong, Hou Huihui   +3 more
doaj  

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Evaluation on cutting performance of novel PDC cutter for pipe jacking machine

Underground Space
It is inevitable to cut reinforced concrete (RC) appeared in cross passage of city metro by cutting tools when constructing in densely populated area. The previous cutters employed to cut RC are insufficient and easily damaged, so a new polycrystalline ...
Long-Chuan Deng, Yi-Xiang Yuan, Xiao-Zhao Li, Qian-Wei Zhuang, Chi Zhang, Yi-Wei Chen   +5 more
doaj   +1 more source