Results 241 to 250 of about 4,657 (257)

P534. Initial Assessment of the Clinical Profile of the PDE10A Inhibitor MK-8189 in Patients With an Acute Episode of Schizophrenia

Biological Psychiatry, 2022
Y. Mukai, R. Lupinacci, S. Marder, M. Mackle, L. Snow-adami, T. Voss, Sean M. Smith, Mike F. Egan   +7 more
semanticscholar   +1 more source

P546. Preclinical Characterization and Phase 1 Evaluation of the Tolerability, Pharmacokinetics, and Enzyme Occupancy of MK-8189, a Novel PDE10A Inhibitor

Biological Psychiatry, 2022
Sean Smith, J. Uslaner, M. Kandebo, E. Hostetler, I. Raheem, M. Layton, L. Gantert, K. Riffel, C. Cox, Sauzanne G Khalilieh, I. Lepeleire, G. Bormans, M. Depré, J. Hoon, K. Laere   +14 more
semanticscholar   +1 more source

Synthesis of a PDE10A Inhibitor

Synfacts, 2019
openaire   +2 more sources

Exploring dimethoxy naphthalenyl methoxyphenyl quinazolinyl amine as a PDE10A inhibitor: In-silico studies, synthesis and binding interactions with serum albumin

Journal of Molecular Liquids
Akanksha Mishra, Pooja Singh, Chandraprakash Gond, Vijay Kumar Singh, A. Tiwari   +4 more
semanticscholar   +1 more source

Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - An update of recent progress.

European journal of medicinal chemistry, 2021
Harsh S Amin, P. Parikh, M. Ghate
semanticscholar   +1 more source

Discovery of PDE10A inhibitor, PF-2545920

Drug Discovery Today, 2010
openaire   +2 more sources

Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [18F]JNJ42259152 PET study in rats

European Journal of Nuclear Medicine and Molecular Imaging, 2021
B. de Laat, Yvonne E. Kling, Gwen Schroyen, M. Ooms, J. Hooker, G. Bormans, K. van Laere, J. Ceccarini   +7 more
semanticscholar   +1 more source

PDE10A: A Striatum-Enriched, Dual-Substrate Phosphodiesterase

2006
Frank Menniti, Christopher Schmidt, Christine Strick   +2 more
openaire   +1 more source

The Potent PDE10A Inhibitor MP-10 (PF-2545920) Suppresses Microglial Activation in LPS-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models

Journal of Neuroimmune Pharmacology, 2020
Do-Yeon Kim, Jin‐Sun Park, Y. Leem, J. Park, Hee-Sun Kim   +4 more
semanticscholar   +1 more source

Loss of PDE10A is associated with metastasis of colon adenocarcinoma.

Histology and Histopathology
Sumaita Arowa, Nicholas Nuechterlein, Vinny Ha, Allison Shelbourn, Ashis Chowdhury, Y. Banasavadi-Siddegowda, J. Lasota, Markku Miettinen, Patrick J Cimino   +8 more
semanticscholar   +1 more source