Results 111 to 120 of about 62,883 (260)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Analysis of the fluctuations of a laser beam due to thermal turbulence

Open Physics, 2014
Ndlovu Sphumelele, Chetty Naven
doaj   +1 more source

Curcumin-mediated photodynamic inactivation of <i>Vibrio parahaemolyticus</i> biofilms on stainless steel: Oxidative damage and degradation of exopolysaccharides. [PDF]

Curr Res Food Sci
Huang X, Chen L, Tang S, Peng Z, Lin Z, Feng K, Wang L, Zhao Y, Zeng Q, Wang JJ.   +9 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Amplified chiroptic response in a multi-helical penta-perylene structure. [PDF]

Chem Sci
Pedersen SK, Steigerwald ML, Nuckolls C, Pittelkow M.   +3 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Evidence of static quenching in the photoredox activity of perylene diimide radical anions: implications for consecutive photoinduced electron transfer photocatalysis. [PDF]

Chem Sci
Sucre-Rosales E, Cruz Neto DH, Vauthey E.   +2 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Surface topography with PDI holography

, 2008
This paper presents topographic measurements of metal surface with Point Diffraction Interferometer (PDI) technique. Interferogram of a surface is created and recorded with different phase offsets. These are then combined to create a phase offset map of the surface.
Bååth, Lars B., Abu Dalou, Sadi Khalid, Rosén, Bengt-Göran   +2 more
openaire   +1 more source

Structural properties, polymorphism, and multiscale disorder unravel energy transport limitations in perylene diimide semiconductors. [PDF]

Sci Adv
Smalley CJH, Hughes CE, Willhammar T, Pandya R, Saikin SK, Johnstone DN, Gorman J, Sung J, Jacucci G, Midgley PA, Kepaptsoglou DM, Ramasse QM, Rao A, Harris KDM, Collins SM.   +14 more
europepmc   +1 more source