Results 141 to 150 of about 190,595 (336)

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

A Comparative Study of Periodontal Disease Index (PDI) Scores in Type-2 Diabetics and Non-Diabetics

, 2022
Sara Mariyum, Rakhshanda Naheed, Zahida Anwar, Amjad Iqbal, Khadija Mariyum, Zia Ur Rehman Khalil   +5 more
openalex   +2 more sources

A trust model for spreading gossip in social networks

, 2019
We introduce here a multi-type bootstrap percolation model, which we call T-Bootstrap Percolation (T-BP), and apply it to study information propagation in social networks.
Bhansali, Rinni, Schaposnik, Laura P.
core  

1P064 Temperature effects on the structure of PDI and reduction rate of inslin by PDI

Seibutsu Butsuri, 2004
K. Ado, R. Maeda, T. Horibe, M. Kikuchi, N. Takeda, Y. Taniguchi   +5 more
openaire   +2 more sources

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Characterization of the Estradiol-Binding Site Structure of Human Protein Disulfide Isomerase (PDI)

, 2011
Xinmiao Fu, Pan Wang, Bao Ting Zhu
openalex   +2 more sources

A contribuição da gestão de projetos para a elaboração do Plano de Desenvolvimento Institucional (PDI) em instituições de ensino superior

, 2021
O. Schmidt, Silvana Veroneze, Cleunice Zanella   +2 more
openalex   +2 more sources

Protein disulfide isomerase is essential for spermatogenesis in mice

JCI Insight
Spermatogenesis requires precise posttranslational control in the endoplasmic reticulum (ER), but the mechanism remains largely unknown. The protein disulfide isomerase (PDI) family is a group of thiol oxidoreductases responsible for catalyzing the ...
Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu   +7 more
doaj   +1 more source

Semiconducting Open‐Shell Radicals for Precise Tumor Activatable Phototheranostics

Advanced Science
Semiconducting open‐shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class of semiconducting perylene diimide (PDI),
Jie Zhang, Haifen Luo, Wen Ma, Jingqi Lv, Bo Wang, Fengwei Sun, Weijie Chi, Zhuting Fang, Zhen Yang   +8 more
doaj   +1 more source