Results 41 to 50 of about 55,070 (279)

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

A fusion positioning method for underground personnel based on UWB and PDR

Gong-kuang zidonghua
Most existing fusion positioning methods for ultra-wideband (UWB) and pedestrian dead reckoning (PDR) ignore the correction of positioning errors in non line of sight (NLOS) environments.
JIA Yutao, LI Guanhua, PAN Hongguang, CHEN Haijian, WEI Xuqiang, BAI Junming   +5 more
doaj   +1 more source

Cost-Effectiveness of Rural Incentive Packages for Graduating Medical Students in Lao PDR [PDF]

International Journal of Health Policy and Management, 2017
Background The dearth of health workers in rural settings in Lao People’s Democratic Republic (PDR) and other developing countries limits healthcare access and outcomes.
Eric Keuffel, Wanda Jaskiewicz, Khampasong Theppanya, Kate Tulenko   +3 more
doaj   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Individual aspect of career adaptability: its relationship with personality traits and affection

Psychiatry and Behavioral Sciences, 2017
Objective: The aim of this study was to examine the relationship between career adaptability with multidimensional perfectionism personality traits and trait anxiety. Method: Cross-sectional and quantitative research methods were used in this study.
Ali Eryılmaz, Ahmet Kara
doaj   +1 more source

Seroprevalence of major bovine-associated zoonotic infectious diseases in the Lao People's Democratic Republic [PDF]

, 2012
Bovine-associated zoonotic infectious diseases pose a significant threat to human health in the Lao People's Democratic Republic (Lao PDR). In all, 905 cattle and buffalo serum samples collected in northern Lao PDR in 2006 were used to determine ...
Khounsy, S, Blacksell, S. D., Thompson, R.C.A., Blacksell, SD, Fenwick, Stanley, Blacksell, S.D., Conlan, J.V., Vongxay, K., Thompson, R. C., Dorny, P., Thompson, RC Andrew, Khounsy, Syseng, Blacksell, Stuart D, Thompson, RC, Khounsy, S., Fenwick, S., Vongxay, K, Dorny, Pierre, Conlan, JV, Conlan, James V, Fenwick, S, Dorny, P, Conlan, J. V., Vongxay, Khamphouth   +23 more
core   +1 more source

Preprint: Hepatitis B virus infection in the Lao PDR: A systematic review

, 2022
Introduction Even though hepatitis B is endemic in the Lao PDR, the understanding of the epidemiology of hepatitis B infection is incomplete. This article reviews the available literature about hepatitis B seroprevalence, risk factors and genotypes in ...
Hefele, Lisa, Nouanthong, Phonethipsavanh, Black, Antony P., Hübschen, Judith M., Muller, Claude P.   +4 more
core   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Diet and prey selection of clouded leopards and tigers in Laos

Ecology and Evolution, 2022
In Southeast Asia, conservation of ‘Vulnerable’ clouded leopards (Neofelis nebulosa) and ‘Endangered’ tigers (Panthera tigris) might depend on the management of their preferred prey because large felid populations are limited by the availability of ...
Akchousanh Rasphone, Anita Bousa, Chantavy Vongkhamheng, Jan F. Kamler, Arlyne Johnson, David W. Macdonald   +5 more
doaj   +1 more source