Results 21 to 30 of about 484,030 (301)

Artificial Intelligence–Based Online Symptom Assessment Tools for Systemic Lupus Erythematosus Diagnosis: Patient Perspectives

Arthritis Care &Research, EarlyView.
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein, Jennifer L. F. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

Integrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases

Scientific Reports
The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and the intracranial time-course ...
Feng Liang, Yimei Zhang, Qian Xue, Xiaoling Zhang   +3 more
doaj   +1 more source

The effect of downregulation of Stathmin gene on biological behaviors of U373 and U87-MG glioblastoma cells

Biological Research, 2018
Background Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma.
Ping Liu, Junyan Yu, Xiangyang Tian, Jianlan Chang, Ying Zhang, Rong Zhang, Ningning Zhang, Ranxing Huang, Lulu Li, Xianli Qiao, Hongliang Guo   +10 more
doaj   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

circ-NOLC1 inhibits the development of cervical cancer by regulating miR-330-5p-PALM signaling axis

Hereditas
Background Recent studies have increasingly demonstrated that circular RNAs (circRNAs) play significant roles in the occurrence and progression of cervical cancer (CC).
Yali Duo, Cong Kang, Lei Zheng, Jing Wang, Zhongjie Liu, FengLing Bi, Lei Qiu, Ning Zhao   +7 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Lung protective ventilation and intraocular pressure in Trendelenburg laparoscopic myomectomy: a randomised trial

Scientific Reports
The Trendelenburg position frequently elevates intraocular pressure (IOP), potentially leading to adverse outcomes, particularly in sensitive patients. Carbon dioxide pneumoperitoneum can exacerbate this effect.
Jianzheng Cheng, Jinbao Wang, Lingling Liu, Zenghua Cai, Yan Di, Xiongwei Yu, Xiaofang Kang, Shuhang Hao, Yu Wu   +8 more
doaj   +1 more source

Adaptive Cu Reconstruction in Heterostructure Drives High‐Rate Nitrate‐to‐Ammonia Conversion

Advanced Science, EarlyView.
An adaptively reconstructed Cu/CoOX heterojunction, featuring a surface‐localized, hydroxyl‐rich oxidized Cu species, forms in situ from a CuO/CoOX (Co1Cu9OX) pre‐catalyst during electrochemical nitrate reduction. The self‐adaptive reconstruction and the incorporation of heterostructure regulate nitrogen‐containing intermediate adsorption and *H supply,
Chunyu Yuan, Saikat Bolar, Yongzheng Zhang, Akitaka Ito, Tatsuhiko Ohto, Takeshi Fujita   +5 more
wiley   +1 more source

Political development predicts reduced human cost of flooding

Nature Communications
Societal impacts from extreme climate and weather events depend not only on hazard magnitude but also on the vulnerability of the affected population. Existing research suggests that adverse socioeconomic conditions are associated with higher baseline ...
Paola Vesco, Nina von Uexkull, Jonas Vestby, Halvard Buhaug   +3 more
doaj   +1 more source

Impact of intravenous dexmedetomidine on gastrointestinal function recovery after laparoscopic hysteromyomectomy: a randomized clinical trial

Scientific Reports, 2022
Postoperative intestinal ileus is common after laparoscopic surgery, the incidence of those after hysterectomy was 9.2%. Anesthesia is one of the independent risk factors of postoperative ileus.
Yu Wu, Zenghua Cai, Lishuang Liu, Jinbao Wang, Yanli Li, Yuling Kang, Ni An   +6 more
doaj   +1 more source